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Lack of suppression of insulin secretion by exercise in patients with insulinoma

, : Lack of suppression of insulin secretion by exercise in patients with insulinoma. Clinical Endocrinology 15(4): 391-394

Serum glucose, insulin and glucagon concentrations were measured in 3 patients with insulin-producing tumors of the pancreas while performing an exercise test. In contrast to the normal adrenergic inhibition of insulin release in response to exercise, plasma insulin concentration remained at a constant and high level during exercise in patients with insulinomas. Their plasma glucose concentrations fell during exercise and in the post-exercise period. No significant changes occurred in plasma glucagon concentration. An exercise test may be a useful new diagnostic tool in organic hyperinsulinism.


PMID: 6274547

DOI: 10.1111/j.1365-2265.1981.tb00679.x

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