+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of suppression of lymphocyte migration inhibition factor production by estradiol progesterone and human chorionic gonadotropin

, : Lack of suppression of lymphocyte migration inhibition factor production by estradiol progesterone and human chorionic gonadotropin. Journal of Reproductive Immunology 1(5-6): 297-306

The hypothesis that hormones produced by the placenta contribute to immunosuppression during pregnancy is an attractive one. To partially evaluate this hypothesis, the migration inhibition factor (MIF) assay was utilized, which is an in vitro model of delayed hypersensitivity in that presensitized lymphocytes stimulated by antigen release a glycoprotein (MIF) which inhibits the normal migration of macrophages. The effect of placental hormones on this model of cellular immunity was tested using the direct and indirect MIF assays in pre-immunized guinea pigs. Estradiol (1-50 .mu.g/ml), progesterone (1-50 .mu.g/ml) and commercial grade or chromatography-purified hCG [human chorionic gonadotropin] (1000-5000 IU/ml) did not affect normal macrophage migration and also failed to suppress production of MIF by guinea pig lymphocytes stimulated with antigen. None of the hormones enhanced or suppressed macrophage response to preformed MIF. These hormones apparently do not suppress lymphocyte reactivity as assessed by the production of lymphokines or the target cell response to the mediator. The reported effects of steroid hormones and crude hCG on other models of cellular immunity were discussed.


Other references

Massin-Short, S.; Fisher, V.Scott.; Bakker, G.; Nieratko, J.; Morgan, S.; Herrmann, J.; Savoia, E., 2013: Administration of emergency preparedness Department of Health And Human Service funds: the experience of state and local health departments. Journal of Public Health Management and Practice 19(2): 192-195

Larrode, P.; Morales, F.; Ramón y Cajal, S.; Domínguez, M.; Mostacero, E., 1992: Peripheral neuropathy and correlation with risk factors in material from autopsies and amputations. A morphological study of a series of 100 human peroneal nerves proceeding from autopsies and amputations of patients hospitalized for different diseases was performed. A relation between the morphologic findings and the risk factors of neuropathy...

Long, Wm, 1989: Habitat manipulations to prevent elk damage to private rangelands. General technical report RM Rocky Mountain Forest and Range Experiment Station US Department of Agriculture Forest Service: (171) 101-103

Laurentaci, G.; Franco, M., 1963: Action Of A Vasodilator On The Evolution Of Renal Lesions Due To Temporary Constriction Of The Vascular Peduncle (Experimental Research). Giornale Italiano di Chirurgia 19: 1-16

Ljunghall, S.; Lithell, H.; Skarfors, E., 1987: Prevalence of renal stones in 60-year-old men. A 10-year follow-up study of a health survey. Information on the occurrence of renal stones was obtained in a health survey of 50-year-old men and at follow-up of the same group 10 years later. At the latter investigation, 338 of 1781 participants (19%) had a history of renal stone formation....

Modestin, J.; Abdel-Rehim, H., 1996: Effect of partially open department on unit atmosphere. Ward atmosphere was assessed with the help of the Ward Atmosphere Scale (WAS) by patients, nurses and physicians on 8 admission units before and after the introduction of the partial open door system. On average, on 45% of the days on which the un...

Milner, S.M., 1977: Activation of mouse spleen cells by a single short pulse of mitogen. Nature 268(5619): 441-442

Tortora, M., 1957: Factors in female genital tuberculosis. Archivio di Ostetricia E Ginecologia 62(3): 125-142

Kennedy, C.H., 1923: The phylogeny and the geographical distribution of the genus Erythemis. University of Michigan Museum of Zoology Miscellaneous Publications, no. 11: 19-22

Celati R.; Grassi S.; Calore C.; Rakotoarimanga, 1990: Overflow thermal springs in Tuscany and northern Latium regions, Italy. Hydrogeology, Selected Papers 1: 451-462