geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of suppressive activity of human primary melanoma cells on the activation of autologous lymphocytes


, : Lack of suppressive activity of human primary melanoma cells on the activation of autologous lymphocytes. Cancer Immunology Immunotherapy 26(1): 61-66

Previous studies have indicated that primary but not metastatic melanomas were able to stimulate the proliferation of autologous (Auto) peripheral blood lymphocytes (PBL) in 73% of cases. On the other hand, 57% of the metastatic melanomas were shown to be suppressive when melanoma cells (Me) were admixed with Auto-PBL stimulated with allogeneic (Allo) PBL or interleukin 2 (IL-2) at the beginning of a 6-day incubation period. Here, we report that the suppressive activity of Me is a functional characteristic associated with a particular stage of the disease. In fact, we found that none of the 11 primary tumors tested were able to inhibit the proliferative response of Auto-PBL to Allo-PBL or IL-2 at all the doses of tumor cells used. The generation of lymphocytes cytotoxic against Auto-Me or K562 was also not inhibited. Of the 11 primary tumors checked for suppression, 8 were able to stimulate Auto-PBL in a primary mixed lymphocyte tumor culture. We conclude that opposite functions, stimulation and inhibition of autologous lymphocyte responses are characteristics of primary and metastatic Me, respectively.

US$19.90

PMID: 3345538

DOI: 10.1007/bf00199849


Other references

Tornoe, K.; Orskov, C.; Clausen, J.T.; Thim, L.; Wulff, B.S.; Holst, J.J., 1999: CART ; A new neurotransmitter in the porcine gastrointestinal tract. Gastroenterology 116(4 PART 2): A1093, April

Korn, E.D., 1982: Actin polymerization and its regulation by proteins from nonmuscle cells. Physiological Reviews 62(2): 672-737

Jain, S.; Sima, D.M.; Ribbens, A.; Cambron, M.; Maertens, A.; Van Hecke, W.; D.M.y, J.; Barkhof, F.; Steenwijk, M.D.; Daams, M.; Maes, F.; Van Huffel, S.; Vrenken, H.; Smeets, D., 2016: Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images. The location and extent of white matter lesions on magnetic resonance imaging (MRI) are important criteria for diagnosis, follow-up and prognosis of multiple sclerosis (MS). Clinical trials have shown that quantitative values, such as lesion volum...

Sheela, K.B.; George, T.E.; Peter, K.V., 2004: Morphological and biochemical traits of selected accessions of bird pepper (Capsicum frutescens L.). Twenty-five bird pepper accessions were evaluated for morphological and biochemical traits in Kerala, India. A wide range of variability was observed among accessions for all morphological traits. Bird pepper accessions were characterized by green...

Kanaly, R.; Bartha, R.; Fogel, S.; Findlay, M., 1997: Biodegradation of (14C)benzo(a)pyrene added in crude oil to uncontaminated soil. To investigate the possible cometabolic biodegradation of benzo(a)pyrene (BaP), crude oil spiked with (7-14C)BaP and unlabeled BaP was added to soil with no known pollution history, to give 34 g of oil and 67 mg of BaP/kg of dry soil. The oil-soil...

Bujalance-Moreno, P.; García-Pinillos, F.; Latorre-Román, P.Á., 2017: Effects of a small-sided game-based training programme on repeated sprint and change of direction abilities in recreationally-trained football players. To examine the effects of 6-week periodized small-sided game (SSG) training intervention on change of direction [COD], sprint and repeated sprint ability [RSA] in recreational male football players. Twenty-three young football players (age: 20.86...

Richardson R.; Riccio D.C.; Molenda S., 1982: Reducing vulnerability to retrograde amnesia treatment can new memory be deactivated?. A series of 6 experiments in rats examined the deactivation of memory as indexed by the attenuation of retrograde amnesia (RA). Experiments demonstrated that a surprising and highly arousing event (a life-threatening situation) during the training...

Kil, W.Jong.; Tofilon, P.J.; Camphausen, K., 2012: Post-radiation increase in VEGF enhances glioma cell motility in vitro. Glioblastoma multiforme (GBM) is among the most lethal of all human tumors, with frequent local recurrences after radiation therapy (RT). The mechanism accounting for such a recurrence pattern is unclear. It has classically been attributed to loca...

Zalev, A.H.; Henderson, R.D.; Marryatt, G.V., 1989: The total fundoplication gastroplasty: surgical procedure and radiologic appearance. The total fundoplication gastroplasty (TFG) consists of a combination of an esophagus-lengthening Collis gastroplasty and suturing of the gastric fundus to the esophagus and neo-esophagus to produce a stable intra-abdominal segment together with a...

Charley, V.L.S., 1937: Investigations on fruit products. X. The commercial production of fruit syrups. The author deals with the first year's operations at the factory set up by H. W. Carter & Co. at Ashton Gate, Bristol, where he was in technical control of the first season's processing. Fruit supplies. Difficulty was encountered in gett...