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Lack of synergism of ampicillin and gentamicin in experimental listeriosis


, : Lack of synergism of ampicillin and gentamicin in experimental listeriosis. Infection 15(1): 40-41

Strain SLCC 4013 of Listeria monocytogenes is susceptible in vitro to ampicillin (MIC 0.5 mg/l) as well as to gentamicin (MIC 0.5 mg/l). Whereas treatment of mice infected with this virulent strain with 0.5 mg ampicillin twice a day resulted in a marked decrease in bacterial counts per spleen, the administration of 2 mg gentamicin twice a day hardly reduced bacterial multiplication. The combination of both drugs was not much more effective than ampicillin alone. Thus, a synergistic effect of both these antibiotics on intracellularly growing bacteria could not be demonstrated.

US$19.90

PMID: 3570481

DOI: 10.1007/bf01646117


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