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Lack of t cell antigen expression on hairy cells of b cell origin after in vitro exposure to phyto hem agglutinin

, : Lack of t cell antigen expression on hairy cells of b cell origin after in vitro exposure to phyto hem agglutinin. Blood 63(4): 958-964

The malignant monoclonal population in [human] hairy cell leukemia (HCL) was variously ascribed to be of myeloid, B or even T cell origin. Hairy cells (HC) may concomitantly or serially express both B and T surface determinants, a phenomenon which, if verified, would be unique among the lymphoproliferative malignancies. At least the majority of HCL are phenotypically of B cell derivation, and the initial B cell phenotype is retained and solely expressed on cultured as well as phytohemagglutinin (PHA) activated monoclonal malignant HC.


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