+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of thirst osmoreceptor dysfunction early puberty and abnormally aggressive behavior in 2 boys

, : Lack of thirst osmoreceptor dysfunction early puberty and abnormally aggressive behavior in 2 boys. Clinical Endocrinology 22(4): 469-478

Two unrelated boys (C.C. 13 yr; J.W. 18 yr) presenting with early puberty and episodes of aggressive behavior were found to have hypernatremia and hypodipsia. Plasma vasopressin (AVP) levels were inappropriately low in relation to plasma osmolality, but the patients did not have diabetes insipidus since 24 h urinary volumes were < 1 liter and the maximal urinary osmolality was 1232 in C.C. and 950 in J.W. Plasma renin activity was elevated (> 2000 mg AI/l/h) although aldosterone concentrations were normal. Excretion of a water load (20 ml/kg) was delayed, but plasma renin and aldosterone fell with increased naturesis. An infusion of 0.85 mol/l saline produced a rise in AVP in C.C. but not in J.W. Insulin and hypotension resulted in the releasing of AVP in both boys suggesting a selective defect of osmoreceptor function. Hyperprolactinemia and an exaggerated PRL [prolactin] response to TRH were also noted but no intracranial lesion was demonstrabled on CT [computed tomography] scan. These boys appear to have a hypothalamic syndrome with early puberty, hyperprolactinemia, hypodipsia and osmoreceptor dysfunction which may be associated with aggressive behavior.


Other references

Brennan, T.J., 2001: Postoperative Models of Nociception. Even though it is a costly, poorly understood problem, very little effort has been dedicated toward research on the mechanisms of acute postoperative pain. Presumably, if we learn more about the etiology of acute incisional pain and the sensory pr...

Jeggo, P.A.; Geuting, V.; Löbrich, M., 2012: The role of homologous recombination in radiation-induced double-strand break repair. DNA double-strand breaks (DSBs) represent the most biologically significant lesions induced by ionizing radiation (IR). HR is the predominant pathway for repairing one-ended DSBs arising in S-phase when the replication fork encounters single-stran...

Chuang, K.S., 1995: Geometric gradient--a new estimation of the surface normal for three-dimensional medical imaging. Medical Physics 22(9): 1437-1439

González-Hachero, J.; Argüelles, F.; Hergueta, R., 1997: Clinical symptoms of Helicobacter pylori infection in children. Anales Espanoles de Pediatria Spec No 2: 242-244

Goff, L.; Cole, K., 1973: The biology of Harveyella mirabilis (Cryptonemiales, Rhodophyceae). I. Cytological investigations of Harveyella mirabilis and its hosts, Odonthalia floccosa. Phycologia 12 (3 4) 237-245

Yao-Tsung Huang; Wang-Nan Wang; Sheng-Feng Wu; Cheng-Yei Shei; Weir-Mirn Hurng; Wun-Hsin Lee; Pieng-Tien Wu, 1990: Formation of the liquid phase in the system Bi-Pb-Sr-Ca-Cu-O. Journal of the American Ceramic Society 73(11): 3507-3510

Jaworek, J.; Nawrot-Porabka, K.; Leja-Szpak, A.; Bonior, J.; Szklarczyk, J.; Kot, M.; Konturek, S.J.; Pawlik, W.W., 2008: Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. Melatonin, the main product of the pineal gland, is also released from the gastrointestinal endocrine-neurocrine (EE) cells. The concentrations of melatonin produced in the gut exceeds that originating from central nervous system. In spite of the...

Chen, G.; Yang, M.; Guo, D., 2009: Metabolic study of ginsenoside Re in rats. To systemically study the metabolism of ginsenoside Re in rats. Six SD rats were used divided into 3 groups. After oral administration of ginsenoside Re at a dosage of 100 mg x kg(-1), feces were collected at 12, 24, 36, 48, and 60 h. The microbia...

Ozdemir, O.; Geyik, B.; Tosun, Oür.; Soylu, M.; Demir, A.Duran.; Alyan, O.; Topaloglu, S.; Aras, D.; Saşmaz, H.; Arda, K.; Korkmaz, S., 2004: Does claudication affect the development of coronary collaterals?. Atherothrombosis is a generalized disease process that affects large- and medium-diameter arteries throughout the arterial tree. In this study, we aimed to evaluate the correlation between collaterals in different vascular beds. Patients who had u...

Wang, D.Y.; Young, S.; Bulbrook, R.D., 1966: The distribution of [1,2-3H]testosterone in the tissues of female rats. Journal of Endocrinology 34(4): 491-496