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Lack of usefulness of bone marrow enzymes and calcium in staging patients with prostatic cancer

, : Lack of usefulness of bone marrow enzymes and calcium in staging patients with prostatic cancer. Cancer 41(4): 1433-1439

Bone marrow acid phosphatase was reported to be a sensitive indicator of early bony metastases from adenocarcinoma of the prostate. To evaluate this hypothesis, bone marrow acid and alkaline phosphatase, lactic dehydrogenase and Ca levels were measured in 84 patients with a variety of problems, including 18 with cancer of the prostate. Bone marrow acid and alkaline phosphatase and lactic dehydrogenase were elevated and Ca was depressed in most patients. Among patients with prostate cancer, bone marrow acid phosphatase was not significantly different between those with or without bone metastases. Patients with prostatic cancer did not have higher levels of bone marrow acid phosphatase than subjects with other malignant and nonmalignant conditions. The level of acid and alkaline phosphatase, lactic dehydrogenase and Ca varied predictably with the aspiration technique used and was independent of sex, disease state or method of chemical determination. Due to this variation, bone marrow enzyme and Ca levels are of no value in the detection of metastases in patients with prostate cancer.


PMID: 639003

DOI: 10.1002/1097-0142(197804)41:4<1433::aid-cncr2820410431>;2-b

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