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Lack of vimentin occurring during the intrafollicular stages of B cell development characterizes follicular center cell lymphomas

, : Lack of vimentin occurring during the intrafollicular stages of B cell development characterizes follicular center cell lymphomas. Blood 71(4): 1033-1038

Reactive germinal-center B cells completely lack vimentin. This observation made by using monoclonal vimentin antibody V9 and a sensitive immunoperoxidase technique led to the investigation of vimentin expression in an unselected series of 73 immunohistochemically proven B cell lymphomas. While small lymphocytic lymphomas regularly expressed vimentin, the neoplastic population of mixed, small and large, and large cell lymphomas often contained various proportions of vimentin-negative tumor cells or failed to express it at all. Against the background of the Lukes-Collins classification and the Kiel classification, both defining and subdividing follicular center-cell lymphomas, there were statistically highly significant correlations between the absence of vimentin and the histology, suggesting a germinal center origin. Our data suggest that loss of vimentin expression is indicative of the transient, follicular center-cell stage of normal and malignant B lymphocytic transformation. The complete absence of vimentin within the neoplastic population of all Burkitt's lymphoma cases examined may serve as an argument for its follicular center stage of differentiation, as was asserted by Lukes and Collins.


PMID: 3258535

Other references

Anderson, W.P.; Hoxworth, G., 1981: Weed control and cotton yields with fluridone treatments. On furrow-irrigated plots, pre-sowing applications of fluridone at 0.28-0.56 kg/ha and trifluralin 0.84 kg + prometryne 1.8 kg gave complete control of weeds including tall morning glory [Ipomoea purpurea] and woolly morning glory [I. hirsutula]....

Dekali, S.; Divetain, A.; Kortulewski, T.; Vanbaelinghem, J.; Gamez, C.; Rogerieux, Fçoise.; Lacroix, G.; Rat, P., 2014: Cell cooperation and role of the P2X₇ receptor in pulmonary inflammation induced by nanoparticles. Macrophages and alveolar epithelial cells are the first targets of inhaled nanoparticles (NPs) reaching the alveoli. Mono- or co-cultures of lung epithelial (A549 or NCI-H441) and macrophage (THP-1) cell lines were used to study the cell cooperati...

Davydov, M.I.; Germanov, A.B.; Lagoshnyĭ, A.T.; Stilida, I.S.; Ter-Ovanesov, M.D., 1999: Main trends in the improvement of surgical treatment results in stomach cancer. According to the data on the treatment of 964 patients with cardioesophageal cancer, the local recurrence incidence fell dramatically (from 19.7 to 4.8%) in patients who had gone extensive surgery. The results of treatment of 1,209 cases operated...

Sillevis Smitt, W.G., 1955: Electro trauma. Nederlands Tijdschrift Voor Geneeskunde 99(47): 3486-3492

Zung, B.J., 1978: Factor structure of the Michigan Alcoholism Screening Test. The Michigan Alcoholism Screening Test (MAST) was administered to 1000 motorists (mean age 42; 67 women) arrested for driving while intoxicated (DWI). The MAST item scores of the entire sample and of subgroups of alcoholics (MAST scores of 5 or ab...

Doolan Barry L., 1987: Geology of the hinterlands; the Gilson Mountain Quadrangle of northern Vermont. The Green Mountain Geologist 13(4): 5-6

Gatenbeck L.; Aronsson A.; Dahlgren S.; Johansson B.; Stromberg L., 1986: Stress and prostatitis. Journal of Urology 135(4 PART 2): 350A

Mertz, Pe, 1986: Southern liberals, the AAA, and the Memphis cotton hearings of 1935. Agricultural legacies: essays in honor of Gilbert C Fite edited by R Alton Lee: 187

Papazian, Michel, 1993: Note on accidental morphological anomalies observed in adult odonates. Entomologiste (Paris) 49(2): 67-78

Dalapathy, S.; Lily, T.K.; Roy, S.; Madhavan, H.N., 1998: Development and use of nested polymerase chain reaction (PCR) for the detection of adenovirus from conjunctivitis specimens. The standard virus isolation method for detecting adenovirus is time consuming and direct detection of viral antigens in smears has its limitations. Therefore a rapid and a reliable method to identify virus in clinical specimens is desirable. To d...