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Lacrimal gland accumulation of gallium 67 labeled citrate in patients with sjogrens syndrome


, : Lacrimal gland accumulation of gallium 67 labeled citrate in patients with sjogrens syndrome. European Journal of Nuclear Medicine 9(5): 233-236

The extent of 67Ga accumulation in the 2 lacrimal glands in patients with keratoconjunctivitis sicca (KCS) of Sjogren's syndrome was studied. Of the 2 main groups 1 consisted of 69 subjects without ophthalmic complaints (control group), the other consisted of 26 patients with KCS of Sjogren's syndrome. Of the 26 patients with KCS, 7 were diagnosed as probable KCS (probable subgroup) and the other 19 had been diagnosed definite KCS (definite subgroup). About 3 mCi (111MBq) 67Ga-citrate was injected i.v. into each subject and this was followed by scintigraphy at 24, 48, and 72 h after the injection of 67Ga. A positive finding in the lacrimal gland was noted in 64 of 69 subjects (92.7%) in the control group and in 7 of 7 patients (100%) with probable KCS. Of 19 patients with definite KCS, 3 (15.7%) showed positive findings under scintigraphy. When the scintigraphic finding in the lacrimal gland is not positive in patients with suspected KCS of Sjogren's syndrome, they can then be diagnosed with little risk as definite KCS cases. Shirmer's test was performed on subjects in the probable and definite groups. There was statistical significance between the positive and equivocal or negative scintigraphic finding and Schirmer's values. These results suggest a correlation between Ga accumulation in the lacrimal gland and the tear production.

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