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Lactase activity after methotrexate experimental study


, : Lactase activity after methotrexate experimental study. Aggiornamento Pediatrico 34(3): 377-382

The response of proximal ileum of postweaning rats to methotrexate, an antagonist to folic acid capable of modifying the proliferation of intestinal epithelium, was studied to value the phases of intestinal atrophy and recovery of lactase activity in relation to histology. The presupposition of a strict morphofunctional correlation does not always occur and enzymatic activity may not be related to the morphologic status of intestinal cell.

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