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Lactate dehydrogenase activity in the presence of certain structural analogs of nad nicotinamide fragment

, : Lactate dehydrogenase activity in the presence of certain structural analogs of nad nicotinamide fragment. Ukrainskii Biokhimicheskii Zhurnal 54(1): 21-25

The activity of lactate dehydrogenase [LDH] from cattle myocardium extract as well as of this enzyme in crystalline form was studied in the presence of structural analogs of the nicotinamide fragment NAD-amide, diethyl amide and N-oxymethyl amide of nicotinic acid. The rate of the reaction catalyzed with LDH under the effect of amide and N-oxymethyl amide of nicotinic acid decreased to a different extent depending on their concentration. Nicotinic diethyl amide practically had no effect on the activity of LDH. Ki for crystalline LDH and myocardium LDH in the presence of nicotinic amide was 0.23 .times. 10-3 and 1.13 .times. 10-3 M, respectively; in the presence of nicotinic N-oxymethyl amide 0.30 .times. 10-3 and 0.10 .times. 10-3 M.


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