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Lactate dehydrogenase and alkaline phosphatase activities in the blood serum and osteogenic sarcomas developed in rats following radiation exposure


, : Lactate dehydrogenase and alkaline phosphatase activities in the blood serum and osteogenic sarcomas developed in rats following radiation exposure. Eksperimental'naya Onkologiya 10(1): 65-68

Alkaline phosphatase (AP) and lactate dehydrogenase (LDG) activities are studied in rat blood serum and osteogenic sarcomas of different histostructure, which developed following a combined exposure of 239Pu (92.5 kBq/kg of body mass) and gamma-irradiation (103.2 mC/kg), as well as following separate exposures to these factors at the same doses. Alkaline phosphatase activities in blood serum and neoplastic bone tissues were found to correlate with the histostructure of osteogenic sarcomas, the distribution and the localization of metastases. Shifts in an isoenzymic spectrum of lactate dehydrogenase in neoplastic bone tissues and blood serum are observed, with a tendency to an increase in the LDG3 and LDG4 and to a decrease in the LDG5 fractions.

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