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Lactate dehydrogenase and its iso enzymes in piglet liver during post natal development

, : Lactate dehydrogenase and its iso enzymes in piglet liver during post natal development. Acta Biologica et Medica Germanica 36(10): 1369-1378

LDH activity in the liver of newborn piglets is 4 times that of adult pig liver and remains relatively constant at this level during the first 3 wk of life. Of the LDH, 90% is localized in the cytosolic compartment of the liver, independent of the age of pigs. In the liver of newborn piglets the isoenzymes LDH-3 and LDH-4 include the main part of LDH activity. The typical distribution of LDH isoenzymes in the liver of adult pigs (LDH-3 > LDH-2 > LDH-1 > LDH-4 > LDH-5) is already reached in 6 day old piglets. This is followed by a decrease of LDH-1. Therefore, during postnatal development a directed shift from M- to H-type of isoenzyme distribution is observed.


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