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Lactate dehydrogenase and malate dehydrogenase isozymes at different stages of the mitotic cycle of ehrlich tumor cells


, : Lactate dehydrogenase and malate dehydrogenase isozymes at different stages of the mitotic cycle of ehrlich tumor cells. Voprosy Onkologii (St Petersburg) 25(7): 60-64

LDH [lactate dehydrogenase] is represented in the [mouse ascites] tumor almost exclusively by an extremely slow migrating isozyme LDH-5. There is no LDH-1, LDH-2 or LDH-3 in the spectrum; LDH-4 is in small amounts. MDH [malate dehydrogenase] is represented by cytoplasmic isozyme (S-MDH) and a mitochondrial fraction (m-MDH). The activity of LDH-5 and S-MDH is altered in a synchronous way: it shows a very sharp increase at the very beginning of the mitotic cycle and reaches the maximum value by mid-S-phase. The m-MDH activity through the cycle is enhanced at the beginning of the cycle and following the termination of S-phase. A direct correlation was found between the activity of m-MDH and the rate of anaerobic glycolysis through the mitotic cycle of Ehrlich tumor cells.

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