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Lactate dehydrogenase ec 1.1.1.27 activity and its iso enzymatic spectrum in the myo cardium of patients with rheumatic heart disease


, : Lactate dehydrogenase ec 1.1.1.27 activity and its iso enzymatic spectrum in the myo cardium of patients with rheumatic heart disease. Kardiologiya 20(4): 93-96

The activity of lactate dehydrogenase (LDH) and its isoenzymatic spectrum were studied in biopsy specimen of the myocardium of 35 patients with mitral valvular disease who underwent operation. Starch gel electrophoresis was used. Four fractions of LDH isoenzymes were detected: LDH1, LDH2, LDH3 and LDH4. A definite metabolic trend of their changes in different stages of the disease was determined. LDH1 activity was considerably increased in patients with stage III mitral stenosis who had complications in the post-operative period. This is evidence of unstable compensation in patients of this group and may indicate the possible development of complications in the early post-operative period.

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