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Lactate dehydrogenase ec 1.1.1.27 iso enzyme 1. its usefulness as a screening test in diagnosis of myo cardial infarction


, : Lactate dehydrogenase ec 1.1.1.27 iso enzyme 1. its usefulness as a screening test in diagnosis of myo cardial infarction. Clinical Biochemistry 16(5): 306-309

Immunological assay of LD-1 [lactate dehydrogenase isoenzyme 1] activity provides a quantitative measurement of the type of lactate dehydrogenase (LD) activity characteristic of myocardial origin. Using this test, a laboratory diagnosis of myocardial infarction can be either ruled out or confirmed in .apprx. 75% of patients in whom this diagnosis is suspected, without electrophoretic separation of creatine kinase (CK, EC 2.7.3.2) and LD isoenzymes. Normal total CK and LD activities cannot be used to rule out myocardial infarction since CK-MB and LD-1 may have increased although total activities remain within their reference ranges. LD-1 activity increases as quickly as CK-MB following the onset of pain in the patients but it remains elevated longer giving a greater period of time during which the diagnosis of myocardial infarction can be confirmed.

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