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Lactate dehydrogenase ec 1.1.1.27 iso enzyme pattern of the pre thymic precursor cell


, : Lactate dehydrogenase ec 1.1.1.27 iso enzyme pattern of the pre thymic precursor cell. Immunology 37(4): 817-820

The thymic cell precursor was obtained from thymic rudiments of 14 day old mouse embryos of strain NMRI. The LDH isoenzyme pattern of this cell population showed a higher LDH-5 activity than the cortical and medullary thymocytes. During the T [thymus-derived] cell development, a shift in the pattern occurs towards the LDH-1 end of the spectrum, as described for other murine tissues and cells. As cortical thymocytes contain less LDH-5 activity than the medullary thymocytes, however, the outcome of the latter cells from the former is in conflict with the shift toward the LDH-1 end of the spectrum. On the contrary a relationship whereby cortical and medullary thymocytes are independently derived from the thymic cell precursor, is consistent with the shift toward LDH-1.

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