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Lactate dehydrogenase ec 1.1.1.27 isozymes in epidermis and skin carcinoma in hamster mesocricetus auratus


, : Lactate dehydrogenase ec 1.1.1.27 isozymes in epidermis and skin carcinoma in hamster mesocricetus auratus. Archives of Dermatological Research 266(3): 233-238

Lactate dehydrogenase (LDH) isozymes in the epidermis and in transplantable epidermal carcinoma from Syrian hamsters were studied by polyacrilamide electrophoresis. A 5-band pattern with occasional loss of 1-2 anode fractions in certain tumor samples is typical. In the epidermis of 14-15 day old fetuses in the regenerating epidermis and in tumor cells cathode or M subunits predominate particularly in the 5th fraction in the last 2 cases. In the epidermis from new born, 25 day old (growing stage of the hairs) and 60-80 day old (resting stage of the hairs) animals a relative increase of the H subunits is striking. A fetal-like pattern of LDH isozymes in regenerating and tumorous epidermis is revealed which is similar to other isozymes in other tissues.

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