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Lactate dehydrogenase ec 1.1.1.27 isozymes of the leopard danio brachydanio nigrofasciatus their characterization and ontogeny


, : Lactate dehydrogenase ec 1.1.1.27 isozymes of the leopard danio brachydanio nigrofasciatus their characterization and ontogeny. Comparative Biochemistry and Physiology B 67(1): 133-138

The tissue specific patterns and ontogeny of lactate dehydrogenase (LDH; EC 1.1.1.27) are reported. While all tissues (eye, brain, heart, intestine, liver, ovary and skeletal muscle) show isozymes of A and B subunit composition, only liver extracts possess isozymes resulting from C subunit synthesis. The A4 homopolymer appears simultaneously with initial muscle contractility and is correlated with the physiological function of muscular contraction. The activation of the Ldh-C locus is correlated with the 1st functioning of liver. The state of differentiation of liver cells may be the stimulus required for C locus expression.

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