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Lactate dehydrogenase in gastric juice and its limitation in the diagnosis of gastric cancer


, : Lactate dehydrogenase in gastric juice and its limitation in the diagnosis of gastric cancer. Annals of Clinical Biochemistry 18(6): 364-367

LDH [lactate dehydrogenase] activity in gastric juice was high in all cases of carcinoma of the [human] stomach investigated provided that the pH of the resting gastric juice was > 5.0. No LDH activity could be detected in gastric aspirate, whether from patients with carcinoma of the stomach or not, when the pH of the resting juice was < 5.0. LDH activity in gastric juice is rapidly and irreversibly inactivated by HCl at a pH of 4.5-5.0.

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