+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lactate dehydrogenase in human cervical mucus: correlation with ovulation, influence of ovarian steroid hormones, and isozyme pattern

, : Lactate dehydrogenase in human cervical mucus: correlation with ovulation, influence of ovarian steroid hormones, and isozyme pattern. Fertility and Sterility 33(2): 135-140

Approximately 20% of all causes of inability to conceive by married couples originate in the uterine cervix. This paper examines: 1) cyclic changes in LDH (lactate dehydrogenase) activity in cervical mucus during the menstrual cycle and the effect of hormone treatment on LDH; 2) the effects of ovarian steroid hormones on LDH activity in the cervical mucus; and 3) changes in LDH isozyme patterns in cervical mucus during the menstrual cycle. Multiple cervical mucus samples were obtained from 96 ovulatory women during their menstrual cycle. The women were divided into: 1) untreated group consisting of 46 infertile women; 2) gonadotropin-treated group of 20 women; 3) clomiphene citrate-treated group of 15 patients, and 4) estriol-treated group of 15 patients. In addition to LDH, the following enzymes were serially measured: glycolytic enzymes, glucose-6-phosphate dehydrogenase, and hexokinase. The cyclic changes in LDH activity proved to be the most significant, being high during the proliferative phase, gradually diminishing to the lowest level around ovulation, and then increasing markedly again. Cervical mucus LDH activity was inhibited by estrogen and accelerated by progesterone. Analysis of the LDH isozyme pattern revealed that H-LDH (a subunit of LDH) predominated throughout the cycle and appeared to be responsible for the cyclic changes in LDH activity. The lowest values for cervical mucus LDH usually appeared between 1 day before and 1 day after the serum LH peak. Daily measurement of cervical mucus LDH activity may be of help in predicting potential day of conception.


PMID: 7353690

DOI: 10.1016/s0015-0282(16)44533-4

Other references

Kincaid Todd R.; Davies Gareth; DeHan Rodney; Hazlett Timothy J., 2004: Characterizing rapid point-recharge to the Floridan Aquifer in the Woodville Karst plain of North Florida; implications for protecting Wakulla Spring. The Woodville Karst Plain (WKP) is a broad lowland that extends from just south of Tallahassee, Florida to the Gulf of Mexico, where the Floridan aquifer is either unconfined or poorly confined. Ground-water flow in the aquifer here is controlled...

Die-Kacou, H.; Kakou, A.; Kamagaté, M.; Yavo, J-Claude.; Bamba-Kamagaté, Dénamba.; Balayssac, E.; Daubret-Potey, Térèse.; Vamy, M-Gboignon., 2012: Sodium and blood pressure in Africa. In the pathophysiology of hypertension, the profile hemodynamic is modified by the relation between the increased sodium intake and blood pressure (BP) level. An increased sodium diet is related not only on the amount of fluid volume within the or...

Charr, R., 1954: Significance of hemoptysis in apparently inactive pulmonary tuberculosis. Twenty-one patients out of 123 with apparently inactive pulmonary tuberculosis had attacks of hemoptysis. The hemoptysis signified relapse of the tuberculosis in only three. In 13 the cause of the pulmonary hemorrhage could not be determined. In o...

Weiss J.; Beversdorf W.D., 1981: Effects of atrazine concentrations on the hill reaction in isolated chloroplasts of triazine resistant and susceptible oilseed rape brassica napus cultivar tower and brassica campestris cultivar torch genotypes. Effects of atrazine concentrations (10-7-10-4 M) on the Hill reaction were evaluated using isolated chloroplasts from parentals, F1 and BC3 [backcross] of triazine-resistant biotype of bird's-rape (B. campestris) .times. B. napus 'Tower&...

Schaafsma, S., 1969: The clinical features of transient ischaemic attacks. A report on 22 cases. Psychiatria, Neurologia, Neurochirurgia 72(1): 115-120

Hill, J.H.; Shepherd, R.J., 1971: Evidence for a single coat protein in Southern Bean mosaic virus. Polyacrylamide gel electrophoresis showed that the coat protein of SBMV consisted of a single polypeptide.

Ige, S.F.; Akhigbe, R.E., 2013: Common onion (Allium cepa) extract reverses cadmium-induced organ toxicity and dyslipidaemia via redox alteration in rats. Cadmium (Cd) remains an important environmental pollutant of public health concern as it causes organ toxicity, and cardiovascular diseases (CVD), but the roles of common foods such as onion (<italic>Allium cepa</italic>) need further...

Edwards, P.; Barry, J.D.; Chatterton, M.C.; Havard, T.J.; Lewis, W.G., 2001: Oesophagogastric cancer and surgical subspecialisation: how much work?. The aim of this study was to assess the volume of work generated by one consultant (out of a surgical unit of seven) managing all the upper gastrointestinal malignancy in a district general hospital serving a population of 480,000. A 3-year period...

Anonymous, 2006: Do usual screening methods for prostate cancer reduce mortality?. Managed Care Interface 19(5): 67-67

Ansari, M.Ikram.; Malik, A., 2008: Genotoxicity of wastewaters used for irrigation of food crops. In most towns of India, wastewater coming from both industrial and domestic sources and without any treatment is used to irrigate the agricultural crops. This practice has been polluting the soil, and pollutants could possibly reach the food chain...