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Lactate dehydrogenase in human cervical mucus: correlation with ovulation, influence of ovarian steroid hormones, and isozyme pattern


, : Lactate dehydrogenase in human cervical mucus: correlation with ovulation, influence of ovarian steroid hormones, and isozyme pattern. Fertility and Sterility 33(2): 135-140

Approximately 20% of all causes of inability to conceive by married couples originate in the uterine cervix. This paper examines: 1) cyclic changes in LDH (lactate dehydrogenase) activity in cervical mucus during the menstrual cycle and the effect of hormone treatment on LDH; 2) the effects of ovarian steroid hormones on LDH activity in the cervical mucus; and 3) changes in LDH isozyme patterns in cervical mucus during the menstrual cycle. Multiple cervical mucus samples were obtained from 96 ovulatory women during their menstrual cycle. The women were divided into: 1) untreated group consisting of 46 infertile women; 2) gonadotropin-treated group of 20 women; 3) clomiphene citrate-treated group of 15 patients, and 4) estriol-treated group of 15 patients. In addition to LDH, the following enzymes were serially measured: glycolytic enzymes, glucose-6-phosphate dehydrogenase, and hexokinase. The cyclic changes in LDH activity proved to be the most significant, being high during the proliferative phase, gradually diminishing to the lowest level around ovulation, and then increasing markedly again. Cervical mucus LDH activity was inhibited by estrogen and accelerated by progesterone. Analysis of the LDH isozyme pattern revealed that H-LDH (a subunit of LDH) predominated throughout the cycle and appeared to be responsible for the cyclic changes in LDH activity. The lowest values for cervical mucus LDH usually appeared between 1 day before and 1 day after the serum LH peak. Daily measurement of cervical mucus LDH activity may be of help in predicting potential day of conception.

US$19.90

PMID: 7353690

DOI: 10.1016/s0015-0282(16)44533-4


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