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Lactate dehydrogenase iso enzyme pattern of uninvolved gastric mucosa of patients with gastric carcinoma and benign gastric disease


, : Lactate dehydrogenase iso enzyme pattern of uninvolved gastric mucosa of patients with gastric carcinoma and benign gastric disease. Digestion 14(1): 20-28

The LDH [lactate dehydrogenase] isoenzyme pattern of the uninvolved mucosa of gastric cancer patients differs from the LDH isoenzyme pattern of similar tissue of patients with benign gastric disease. The former tissue is characterized by a high M/H ratio of the LDH isoenzymes (M and H subunits). A high M/H ratio characterizes antral mucosa when the latter is compared with fundic mucosa. Mucosa showing superficial and atrophic gastritis also has a higher M/H ratio, whereas the presence of intestinal metaplasia does not appear to influence the M/H ratio. These observations are consistent with the concept that the tissue from which the cancer arose may possess a premalignant biochemical lesion.

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