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Lactate dehydrogenase isozymes in the brain under varying conditions of oxygen deficiency


, : Lactate dehydrogenase isozymes in the brain under varying conditions of oxygen deficiency. Voprosy Meditsinskoi Khimii 24(1): 31-35

Spectrum of lactate dehydrogenase (LDH) isozymes and their activity were compared in rat brain tissue under circulatory and hypoxic forms of hypoxia. Dynamics and manifestation of alterations observed correlated primarily with the type of O2 deficiency and with its severity and length of action. Development of O2 deficiency in brain tissue was accompanied by increase in total LDH activity and by elevation in content of M-subunits, typical for anaerobic spectrum of LDH isozymes, with simultaneous decrease in amount of H-subunits.

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