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Lactate dehydrogenase isozymes in transplantable hamster tumors with different histogenesis and differentiation


, : Lactate dehydrogenase isozymes in transplantable hamster tumors with different histogenesis and differentiation. Archiv fuer Geschwulstforschung 51(2): 174-178

LDH [lactate dehydrogenase] isozymes were assayed by polyacrylamide gel electrophoresis in 6 long-term transplantable skin tumors in Syrian hamsters. The percentages of the M-subunits were as follows: in a slow growing fibrosarcoma with abortive differentiation and producing lung metastases.sbd.63.3; in 2 well differentiated squamous cell carcinomas with moderate growth.sbd.79.8 and 74.9; in a slow growing and metastasing melanotic melanoma.sbd.67.7; in undifferentiated amelanotic and depigmented melanomas with very fast growth.sbd.72.8 and 77.4. No consistant relationship has emerged between histogenesis, growth rate, differentiation and metastases, and the LDH isozyme pattern of the studied neoplasms.

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