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Lactate dehydrogenase zymograms of skin biopsies in patients with leprosy. A preliminary report

, : Lactate dehydrogenase zymograms of skin biopsies in patients with leprosy. A preliminary report. International Journal of Leprosy and Other Mycobacterial Diseases 48(4): 426-430

LDH [lactate dehydrogenase] isoenzymes were studied in tissue extracts of 78 cases of leprosy. All 25 control tissues showed 5 LDH isoenzymes corresponding to those of human sera. All tissues from the leprosy cases showed 5 similar bands. Seventeen cases showed additional LDH isoenzymes (anomalous bands). In 12 cases there was a single extra band with an eF value of either 0.125 .+-. 0.015 or 0.525 .+-. 0.015 and 5 cases showed both these bands. Additional bands were observed only in cases positive for acid-fast microorganisms (17 of 27 cases) and their presence correlated well with bacterial load (as judged by the BI [bacterial index]) and viable organisms (as judged by the MI [morphological index]). Four cases with a high BI and MI did not show anomalous bands. A plausible explanation for these bands is that they originate from viable M. leprae.


PMID: 7193657

Other references

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