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Lactate generation by liver in hemorrhagic shock

, : Lactate generation by liver in hemorrhagic shock. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 168(2): 222-227

Hemorrhagic shock caused a decreased hepatic vein P[partial pressure]O2 and pH. This anoxia and acidosis was associated with an increased hepatic vein lactate greater than the arterial and portal vein lactate. This is a reversal of the normal state in which the liver is a consumer of lactate. The normal lactate relationship readily returned following reinfusion of the blood if the hepatic vein PO2 and pH returned to normal. Following a subsequent hemorrhage and reinfusion, the liver continued to produce lactate and the hepatic vein pH remained acidotic, even though the hepatic vein PO2 returned to the control level. Previous studies had shown that catheterization of the hepatic veins in the dog traumatized the liver and the blood samples from that catheter may be misrepresentative of the true state of hepatic venous blood. A study of the level of lactate, PO2, pH, PCO2 and indocyanine green (ICG) compared blood specimens obtained from individually cannulated hepatic veins to those from a common hepatic venous channel (CHVC). Hepatic blood samples from the 2 sites showed no differences for lactate, pH, PCO2 and ICG in the range studied. The CHVC was more dependable for obtaining specimens during profound shock and gave more valid PO2 levels for the lower O2 tensions below 15 mm Hg.


PMID: 6815659

DOI: 10.3181/00379727-168-41264

Other references

Fintha, I., 1968: Beobachtungen uber den Bienenfresser Merops apiaster, seine Brutverhaltnisse, seine Nahrung an der Szamos. Aquila, 75: 93-109

Sholkovitz Edward R., 1985: Redox-related geochemistry in lakes; alkali metals, alkaline-earth elements, and (super 137úCs. 61: 119-142 1985

Tomov, I., 1968: Progeny testing rams for fattening. To investigate the possibility of developing wool and mutton strains of the new Dobruja Finewool breed, 5 from lines selected for high body weight and 5 from lines selected for wool production were each tested by 10 progeny. Average daily weight g...

Cludts, Marcel., 1998: Annotated list of Bostrychidae types Coleoptera of the Belgian Institute of Natural Sciences Liste commentee des types de Bostrychidae Coleoptera de lInstitut royal des Sciences naturelles de Belgique. Bulletin and Annales de la Societe Royale Belge d'Entomologie. 1997( ) Octobre-Decembre; 1334: 471-483

Brink H.J.; Stuempel H., 1989: Geophysical survey of the Haithabu archaeological site. Die Geowissenschaften (Weinheim, Zeitschrift) 7(8): 225-229

Wingard, L.B.; Castner, J.F.; Miyawaki, O.; Marrese, C., 1984: Rotating ring-disc electrode: its use in studying mass transport resistances through immobilized enzyme support matrices. Annals of the New York Academy of Sciences 434: 224-231

Chen, X.; Zhang, M.; Zhu, X.; Deng, Q.; Liu, H.; Larmonier, N.; Graner, M.W.; Zhou, B., 2009: Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. Journal of Infectious Diseases 200(3): 399-408

Errichiello, C.; Marcarelli, M.; Pisani, P.C.; Parino, E., 2013: Treatment of dynamic claw toe deformity flexor digitorum brevis tendon transfer to interosseous and lumbrical muscles: a literature survey. The authors report the results of a literature survey of corrective surgical treatment based on FDL and FDB tendon transfer for dynamic claw toe deformities. The study revealed that FDL transfer was first described in 1967 by Malcolm A. Brahms in...

Berrut, G., 2011: Disability or loss of autonomy. Geriatrie et Psychologie Neuropsychiatrie du Vieillissement 9(2): 133-134

Cerone, D.M.; Cicalese, G.T., 1959: Term abdominal pregnancy with living fetus: report of a case. Obstetrics and Gynecology 14: 368-369