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Lactate kinetics in exercising Thoroughbred horses: regulation of turnover rate in plasma

, : Lactate kinetics in exercising Thoroughbred horses: regulation of turnover rate in plasma. American Journal of Physiology 253(6 Pt 2): R896-R903

Plasma lactate turnover rate of Thoroughbred race-horses was measured by bolus injection of [U-14C]lactate at rest and two levels of submaximal treadmill exercise (3-4 m/s trot, 6% incline, and 6.5 m/s horizontal canter). Our goals were 1) to determine the relative effects of changes in cardiac output and in plasma lactate concentration on turnover rate [using cardiac output data from Weber et al. (28)] and 2) to assess the importance of lactate as a metabolic fuel in a trained animal athlete. Lactate turnover rates were 9.3 .mu.mol .cntdot. min-1 .cntdot. kg-1 (rest), 75.9 .mu.mol .cntdot. min- 1 .cntdot. kg-1 at the beginning of the trot oprotocol [45% maximum O2 uptake (.ovrhdot.VO2)], 50.3 .mu.mol .cntdot. min-1 .cntdot. kg-1 during the canter protocol (55% (.ovrhdot.VO2). Both changes in cardiac output and in plasma lactate concentration had a significant effect on turnover rate. Variation in plasma lactate fluxes of Thoroughbreds during exercise follows the standard mammalian pattern, but this substrate only plays a minor role as an oxidizable fuel in horses. The oxidation of plasma lactate accounts for less than 5% of metabolic rate (.ovrhdot.VO2) during submaximal work. Adjustments in cardiac output and in metabolite concentration represent, respectively, the coarse and fine controls for the regulation of plasma metabolite turnover rate.


PMID: 3425768

DOI: 10.1002/ajpa.1330740313

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