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Lactate metabolism of the oral bacterium veillonella from human saliva

, : Lactate metabolism of the oral bacterium veillonella from human saliva. Archives of Oral Biology 26(8): 657-662

Lactate is metabolized by Veillonella via the methylmalonyl-CoA pathway to propionate and, by further pathways, to acetate. Whereas pyruvate and oxaloacetate are metabolized via the pyruvate-formate lyase reaction, lactate acts as a donor of H2 allowing the reduction of oxaloacetate to malate in the methylmalonyl-CoA pathway. Succinate, believed to be an intermediate in lactate metabolism of Veillonellae is readily decarboxylated to propionate by these organisms, but a severe, progressive substrate inhibition occurs at concentrations above 12-16 mmol/l.


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