+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lactate, muscle glycogen and exercise performance in man

, : Lactate, muscle glycogen and exercise performance in man. Acta Physiologica Scandinavica. Supplementum 495: 1-35

The effects of changes in glycogen concentrations, induced by either exercise or a combination of exercise and diet, on lactate accumulation in human skeletal muscle during a 1 min high intensity muscle fatigue test were investigated. High and similar lactate concentrations were observed over a wide range of glycogen levels. Lactate was significantly reduced when glycogen levels were < 40 mmol glucosyl units kg-1. When acute glycogen depletion in both main groups of muscle fibers was induced by exercise, subsequent muscle strength and muscle power were impaired. Subjects with muscle rich in FT [fast twitch] fibers demonstrated a greater impairment than those rich in ST [slow twitch] fibers. If exercise-induced glycogen depletion was limited to the ST muscle fiber population, no significant impairment of muscle force was observed while torgue decline during repeated maximal contractions was increased, i.e., the muscle was more susceptible to fatigue. Endurance exercise capacity was closely related to the exercise intensity at which a blood lactate accumulation of 4 mmol 1-1 occurred and to the ability to exercise at an intensity close to that intensity during a competition. These properties were in turn related to the percentage of ST muscle fibers, capillary density, muscle enzyme activities and training volume. Skeletal muscle LPL [lipoprotein lipase] activity was positively related to percent of ST fiber frequency in the normal state. A fat and protein rich diet during 3-4 days was associated with a 21% increase in LPL activity while a carbohydrate rich diet during 4 days was associated with a 51% decrease in LPL activity. The extent of the decrease in LPL activity after the carbohydrate-rich diet was positively related to % ST muscle fiber and to the extent of the increase in glycogen concentration.


PMID: 6950657

Other references

Hart, T.; Whyte, J.; Watanabe, T.; Chervoneva, I., 2017: Effects of dextroamphetamine in subacute traumatic brain injury: A randomized, placebo-controlled pilot study. Psychostimulants that affect neurotransmitters implicated in cognitive function and neural plasticity have potential to enhance the rate and extent of recovery after traumatic brain injury (TBI). Ten milligrams dextroamphetamine (DEX) or an identi...

Benedetti C.; Bonica J.J.; Bellucci G., 1984: Pathophysiology and therapy of postoperative pain a review. Benedetti, C , C R Chapman And G Moricca (Ed ) Advances in Pain Research And Therapy, Vol 7 Recent Advances in The Management Of Pain; Symposium, Palermo, Italy, 1981 Xix+692p Raven Press: New York, N Y , Usa Illus 373-408

Zenzola, M.; Degennaro, L.; Trinchera, P.; Carroccia, L.; Giovine, A.; Romanazzi, G.; Mastrorilli, P.; Rizzi, R.; Pisano, L.; Luisi, R., 2015: Harnessing the ortho-directing ability of the azetidine ring for the regioselective and exhaustive functionalization of arenes. This work demonstrates how the directing ability of the azetidine ring could be useful for regioselective ortho-C-H functionalization of aryl compounds. Robust polar organometallic (lithiated) intermediates are involved in this synthetic strategy....

Rao, Cgp, 1972: Anatomical studies of Puccinia galls on Urtica parviflora. Indian phytopathology: (Pub y 1972), 24 (4) 765-768

Munro, J.; Briggs, J.D.; McCruden, E.A., 1996: Detection of a cluster of hepatitis C infections in a renal transplant unit by analysis of sequence variation of the NS5a gene. Hepatitis C virus (HCV) genotype 1 isolates from 31 patients on dialysis or with renal transplants were studied for evidence of patient-to-patient spread of infection. Nucleotide sequences from a variable region (NSSV) of the NSSa (nonstructural 5...

Yamasaki H.; Martel N.; Fusco A.; Ostertag W., 1984: Continuous suppression of globin gene expression and differentiation of friend erythro leukemia cells by phorbol 12 myristate 13 acetate despite the loss of phorbol 12 myristate 13 acetate binding sites by down regulation. The tumor promoter phorbol 12-myristate 13-acetate (PMA) reversibly inhibits hexamethylene bisacetamide-induced terminal differentiation of Friend erythroleukemia cells (FELC). FELC differentiation was inhibited by PMA up to 125 wk (.apprx. 240 se...

Giordano, S.; Paganini, G.; Bezante, T., 1969: Spirographic determination in pediatrics. Determination of various indexes of respiratory function in 68 normal children and in 32 children with bronchial asthma (preliminary note). Minerva Pediatrica 21(40): 1856-1863

Perosa, F.; Rizzi, R.; Dammacco, F., 1994: Soluble CD4 and commercial immunoglobulin. Lancet 343(8913): 1638-1638

Chandley, A.C.; Hotta, Y.; Stern, H., 1977: Biochemical analysis of meiosis in the male mouse. I. Separation of DNA labelling of specific spermatogenic stages. Spermatogenic cells of the mouse have been separated by gravity sedimentation using a modification of a previously published method. Details are given for the collection of purified samples of specific meiotic stages and for the collection of labe...

Fiaschi, E.; Galdi, F., 1957: Francesco Galdi. La Riforma Medica 71(7): 189-190