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Level of cobalamins in rats with implanted zajdela ascites hepatoma


, : Level of cobalamins in rats with implanted zajdela ascites hepatoma. Prikladnaya Biokhimiya i Mikrobiologiya 13(1): 74-78

The level of cobalamins in the kidney and liver of healthy rats and rats with implanted Zajdela ascites hepatoma (ZAH) was examined. The results were compared with data obtained from rats with sarcoma M-1. Different tumors had dissimilar effects on the level of total cobalamins. The ratio of free cobalamins to protein bound cobalamins (cobalamin-protein complexes) varied. The concentration of cobalamin-protein complexes increased in the liver, kidney and tumor. ZAH cells contained appreciable amounts of cobalamins, whereas the supernatant contained only a minor quantity of cobalamins. Injections of 5'-deoxyadenosyl-B12 increased the level of cobalamins in ZAH cells and had a low effect on the level of cobalamins in the supernatant.

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