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Levels of malondialdehyde production in rat liver following loading and unloading with iron


, : Levels of malondialdehyde production in rat liver following loading and unloading with iron. Virchows Archiv B Cell Pathology Including Molecular Pathology 45(2): 139-146

Rats were given daily injections of an iron-sorbitol-citric acid complex in a total dose of 50 mg Fe3+/100 g of body wt and either killed immediately after Fe loading or investigated 2 mo. later. Among the latter animals, 1 group was subjected to weekly phlebotomies in order to mobilize Fe from the stores, while another group was not further treated. Quantitation of Fe and malondialdehyde production was performed on homogenates of liver, kidney and spleen from controls and rats in the different experimental groups, and the distribution of Fe in granular form was studied in the livers by means of EM. The results showed substantially increased amounts of Fe in the organs studied after Fe-loading and also augmented malondialdehyde production in the liver and kidney (but not in the spleen). A decreased malondialdehyde production was recorded 2 mo. after Fe-loading in the kidney and spleen of nonbled animals; this decrease was exaggerated in the same organs from bled animals. The production of malondialdehyde as well as the Fe content in the livers of both bled and nonbled rats 2 mo. after Fe loading was higher than in the controls. The accumulation of Fe in the liver was apparently causally related to increased lipid peroxidation. Judging from the morphological appearances this change did not result in cell damage, the only pertinent morphologic alteration being the occurrence of Fe particles in the lysosomal vacuome and the cell sap.

US$19.90

PMID: 6143442

DOI: 10.1007/bf02889860


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