+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Levels of malondialdehyde production in rat liver following loading and unloading with iron

, : Levels of malondialdehyde production in rat liver following loading and unloading with iron. Virchows Archiv B Cell Pathology Including Molecular Pathology 45(2): 139-146

Rats were given daily injections of an iron-sorbitol-citric acid complex in a total dose of 50 mg Fe3+/100 g of body wt and either killed immediately after Fe loading or investigated 2 mo. later. Among the latter animals, 1 group was subjected to weekly phlebotomies in order to mobilize Fe from the stores, while another group was not further treated. Quantitation of Fe and malondialdehyde production was performed on homogenates of liver, kidney and spleen from controls and rats in the different experimental groups, and the distribution of Fe in granular form was studied in the livers by means of EM. The results showed substantially increased amounts of Fe in the organs studied after Fe-loading and also augmented malondialdehyde production in the liver and kidney (but not in the spleen). A decreased malondialdehyde production was recorded 2 mo. after Fe-loading in the kidney and spleen of nonbled animals; this decrease was exaggerated in the same organs from bled animals. The production of malondialdehyde as well as the Fe content in the livers of both bled and nonbled rats 2 mo. after Fe loading was higher than in the controls. The accumulation of Fe in the liver was apparently causally related to increased lipid peroxidation. Judging from the morphological appearances this change did not result in cell damage, the only pertinent morphologic alteration being the occurrence of Fe particles in the lysosomal vacuome and the cell sap.


PMID: 6143442

DOI: 10.1007/bf02889860

Other references

Anonymous, 1961: Summary of FAO. A summary is presented of a 1961 FAO/WHO/IAEC meeting concerning the wholesomeness of foods following their irradiation. This summary includes 4 technical papers and a list of general conculsions and recommendations. Specific areas for further nee...

Papamichail, M.; Brown, J.C.; Holborow, E.J., 1971: Immunoglobulins on the surface of human lymphocytes. Lancet 2(7729): 850-852

Prevot, G.; Bartoli, P.; Deblock, S., 1976: The life cycle of Maritrema misenensis (A. Palombi, 1940), n. comb. (Trematoda: Microphallidae, Travassos, 1920) from French Mediterranean coast. The life cycle of Maritrema misenensis (A. Palombi, 1940) n. comb. is described with illustrations. The sporocysts parasite the digestive gland of the Prosobranch snail Cerithium mediterraneum. The cercariae are the same as Cercaria misenensis, A....

Cramer D., 1991: Neuroticism psychological distress and conjugal bereavement. In an attempt to determine the extent to which the Eysenck Personality Inventory measure of Neuroticism reflects transient psychological distress as assessed by the 30-item General Health Questionnaire, the correlation between these two measures a...

Anonymous, 1956: Nursery fertilisers affect planting survival. Type of fertilizer and, rate, time, and frequency of application affected the survival rate of transplanted Slash Pine seedlings.

Brunori, A.; Georgieva, J.; D'amato, F., 1970: Further observations on the X-irradiation response of G1 cells in dry seeds. X irradiation of dry seeds of Pinus pinea, Helianihus annuus and Lactuca sativa induced mainly chromosome breakages in G1 cells. The fewer chromatid breakages found were attributable to: (1) the meristems containing a fraction of their G 1 cells i...

Saric, T.; Burlica, L., 1974: The possibility of chemical weed control in plum orchards. Two-year herbicide trials were carried out at 2 localities in Yugoslavia in 11-year-old plum orchards which had not been regularly cultivated for many years though the wild grasses had been mown regularly. Of 17 herbicides tested, Casoran (dichlob...

Anonymous, 1958: 34th descriptive varietal list of agricultural crops, 1959. The present edition of this useful book follows the same plan as its predecessors . Covering all the main crops grown in the Netherlands, it lists and provides descriptive notes on all the most important varieties. Information on the parentage of...

Gee, Henry., 1996: Before the backbone views on the origin of the vertebrates. Unknown

Drouet T.; Herbauts J.; Demaiffe D., 2005: Strontium isotopes highlight change in Ca sources in forest ecosystems. Geochimica et Cosmochimica Acta 69(10, Suppl