geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Light and electron microscopic studies on glycogen inclusions in the parathyroid cell nuclei of cattle


, : Light and electron microscopic studies on glycogen inclusions in the parathyroid cell nuclei of cattle. Kaibogaku Zasshi. Journal of Anatomy 60(5): 605-622

Nuclear glycogen (NG) has been studied widely in healthy and pathological cells of a wide variety of organs and animals, ranging from invertebrates to man. However, only little work has been made on the NG in endocrine organs since Hoshino and Okada (1969) found NG in the cattle parathyroid gland and made some fundamental investigations by means of light microscope. The present report deals with NG by light and electron microscope on 24 parathyroid glands from 20 cattle and some interesting results are obtained. In the initial step of NG deposition, glycogen appears near the nucleolus as a little deposit, mainly consisting of .gamma. particles together with a little .beta. particles and also scattered .gamma. particles in interchromatin spaces. The initiation of NG as .gamma. particles observed here has not been reported so far. This may be due to the lack of observations on the earlier stage by the other investigators. Otherwise, Ferrans et al. (1975) summarized previous results in many types of the granurality and morphological feature of later stages of NG. According to their criteria, our findings on NG belong to such category that NG grows up to a large deposit of only .beta. particles in the nuclear center. In addition, neither .alpha.-particles nor .beta. particles are surrounded by a fibrous halo, as observed previously by Caramia et al. (1967). Our results show no direct relationship between the cytoplasmic and nuclear glycogens as reported by several authors. On the other hand, outer nuclear membrane disappears, and nuclear pores open with increase in the amount of glycogen, which is likely to flow out through opened nuclear pores at the final stage. On the basis of various morphological features of NG reported previously, the two dominant theories are quoted for origins of NG, namely the infiltration of cytoplasmic glycogen and the synthesis of glycogen in nuclei. However, recent autoradiographic methods using 3H-glucose show a prompt occurrence of silver grains in interchromatin spaces even at the early stage where no glycogen is recognized with following increase in both silver grains and .beta. glycogen particles. Therefore, it is sure that NG may be synthesized in the nucleus from the glucose transported from cytoplasm to .beta. or .alpha. particles via .gamma. as shown in the present report, with the aid of synthetic enzymes probably from cytoplasm through nuclear pores, though little infiltration of cytoplasmic glycogen of any types are still undeniable. The frequency values per glandular cells varied within the range of 0-50%, where the higher rates are exclusively for the Japanese black cattle strain. This suggests some differences in occurrence of NG with respect to strains, but there are no sexual or castrational superiorities as reported of the prelingual glands of hen, and of suprarenal glands of pig. As to the tendency of the progress of NG in the organs, little has been discussed in many reports only suggesting its gradual increase. From results of Toryu et al. (1961 a), a normal distribution curve of NG in the prelingual glands of hen can be recognized. However, as explained in Table 2 (column B), three different types can be found with our materials. Of these types, the last two exhibit characteristic distribution patterns. From these patients, it may be supposed that NG progresses not continuously but intermittently with a sudden argumentation of glycogen-including nuclei and a period of dormancy.

US$29.90

PMID: 3006420


Other references

Miszczyk, L.; Tukiendorf, A.; Jochymek, B., 2013: Linac based radical radioablation of liver tumors. Due to the low percentage of resectable liver tumors, new alternative treatment modalities are used. Among them, radioablation, that is, by using a limited number of high dose radiation. The aim of this study was to evaluate the effectiveness of l...

Levitt, R.; Buckner, J.C.; Cascino, T.L.; Burch, P.A.; Morton, R.F.; Westberg, M.W.; Goldberg, R.M.; Gallagher, J.G.; O'Fallon, J.R.; Scheithauer, B.W., 1995: Phase II study of amonafide in patients with recurrent glioma. Amonafide, a novel imide derivative with broad preclinical antitumor activity, achieves significant cerebrospinal fluid levels in animal models. In order to test its antitumor activity in patients with recurrent diffuse infiltrative glioma of the...

Wolter, H.H.; Schmitz, W., 1969: Heart disorders following surgery using extracorporeal circulation. Thoraxchirurgie, Vaskulare Chirurgie 17(5): 442-454

Kaiser, B.; Hauptmann, J.; Weiss, A.; Markwardt, F., 1985: Pharmacological characterization of a new highly effective synthetic thrombin inhibitor. The most potent synthetic reversible thrombin inhibitor described so far, N.alpha.-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidine (Ki = 6 nmol/l), was studied with respect to its pharmacodynamics and pharmacokinetics in mice, rats an...

Barakat, M.A.; Ramadan, M.H.; Alghamdi, M.A.; Algarny, S.S.; Woodcock, H.L.; Kuhn, J.N., 2013: Remediation of Cu(II), Ni(II), and Cr(III) ions from simulated wastewater by dendrimer/titania composites. Generation 4 polyamidoamine (PAMAM) dendrimers with ethylenediamine cores (G4-OH) were immobilized on titania (TiO(2)) and examined as novel metal chelation materials. Characterization results indicate both the effective immobilization of dendrime...

Raman, T.R.S.ankar; Menon, R.K.G.; Sukumar, R., 1996: Ecology and management of chital and blackbuck in Guindy National Park, Madras. We studied population size, density, and structure, seasonal habitat use, and feeding habits of chital and blackbuck in the 2.7 km-2 Guindy National Park, in Madras, Tamil Nadu, using line-transect sampling during 1991-92, and compared these with...

Biancardi, E.; Casarini, B.; Venturi, G.; Bartolucci, R.; Beltrami, G.; Usai, M.; Zaccarini, D.; Ghedini, R.; Zocca, A.; Tugnoli, V.; Fontana, F.; Pritoni, G.; Rosso, F.; Aguzzoni, G.; Magnani, P.; Ricci Curbastro, G.; Cerato, C.; Grasi, G.; Borrelli, C.; Gatto, A. del; Mambelli, S.; Mantovani, C., 1990: The productivity of sugarbeet in different environments in central-northern Italy. 3rd contribution. Results are tabulated from trials of 4 sugarbeet cultivars undertaken at 27 locations in 1986-88. Data on sugar yields and rhizomania occurrence are included. Cv. Kawegigamono gave the highest av. root yields of 77.1 and 68.5 t/ha in 1986 and 1987...

Dragan, V.S.mic; Petrovic, M.; Matic, D.; Kalimanovska Ostric, D.; Arandjelovic, A.; Seferovic, P.M.; Avramovic, D., 1997: Efficacy of antihypertensive treatment with cilazapril. Cardiovascular Drugs & Therapy 11(SUPPL 2): 344

Bulbarelli, A.; Valentini, A.; DeSilvestris, M.; Cappellini, M.D.; Borgese, N., 1998: An erythroid-specific transcript generates the soluble form of NADH-cytochrome b5 reductase in humans. Two forms of NADH-cytochrome b5 reductase (b5R), an erythrocyte-restricted soluble form, active in methemoglobin reduction, and a ubiquitous membrane-associated form involved in lipid metabolism, are produced from one gene. In the rat, the two for...

Kunos, C.A.; Olszewski, S.; Espinal, E., 2015: Impact of nurse navigation on timeliness of diagnostic medical services in patients with newly diagnosed lung cancer. The Summa Cancer Institute in Akron, Ohio, sought to improve access to and the timeliness of lung cancer care by hiring an oncology-certified nurse navigator. The nurse navigator was charged with coordinating diagnostic procedures and specialty on...