+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Linked aryl aryloxy propanolamines as a new class of lipid catabolic agents

, : Linked aryl aryloxy propanolamines as a new class of lipid catabolic agents. Journal of Medicinal Chemistry 21(2): 182-188

The synthesis of a series of stilbene, biaryl, tolane, diaryl ether, sulfide, sulfoxide and sulfone oxypropanolamines as potential antiobesity agents is described. These compounds were evaluated in a mouse lipid catabolism screen, and the more active members of the series were further investigated in rats and dogs. 1-(2,6-Di-tert-butyl-4-trans-styrylphenoxyl)-3-isopropylamino-2-propanol possessed considerable lipid catabolic activity in mice and caused a significant reduction in the body weight of rats after 5 wk and of dogs after 6 wk. Only hematological irregularities in a chronic toxicity study precluded further development of this compound as an alternative antiobesity treatment.


PMID: 621713

Other references

Rego A.F.M.; Veiga A.F.S.L.; Rodrigues Z.A.; Oliveira M.L.D.; Reis O.V.D., 1986: Effect of the incidence of zabrotes subfaciatus bohemann 1833 coleoptera bruchidae on genotypes of phaseolus vulgaris l. The work was conducted in the Laboratory of Radioentomology of the Nuclear Energy Department of Pernambuco Federal University [Brazil], to evaluate the behavior of 8 likely genotypes of beans Phaseolus vulgaris L. in relation to the incidence of Z...

Ziman, M.R.; Thomas, M.; Jacobsen, P.; Beazley, L., 2001: A key role for Pax7 transcripts in determination of muscle and nerve cells. Embryonic teratocarcinoma mouse cells (P19) and embryonic NIH3T3 fibroblasts were induced chemically to differentiate along neurogenic or myogenic lineages. The expression profiles of Pax7 alternate transcripts were then assessed by RNA isolation...

Wegner, A., 1985: Subtleties of actin assembly. Nature 313(5998): 97-98

Radkevich I.A.; Kolotygina I.M.; Kabakov Yu, 1985: Stability of the membrane potential of mouse liver cells on exposure to damaging agents. Biophysics (English Translation of Biofizika) 30(4): 703-707

Lellouche, Fçois.; Pignataro, C.; Maggiore, S.Maurizio.; Girou, E.; Deye, N.; Taillé, S.; Fischler, M.; Brochard, L., 2013: Short-term effects of humidification devices on respiratory pattern and arterial blood gases during noninvasive ventilation. The impact of humidification devices on ventilatory and arterial blood gases parameters during noninvasive ventilation (NIV) remains controversial. The aim of the study was to compare the short-term impact of heat and moisture exchangers (HMEs) an...

Mohn, J.; Gutjahr, W.; Toyoda, S.; Harris, E.; Ibraim, E.; Geilmann, H.; Schleppi, P.; Kuhn, T.; Lehmann, M.F.; Decock, C.; Werner, R.A.; Yoshida, N.; Brand, W.A., 2016: Reassessment of the NH 4 NO 3 thermal decomposition technique for calibration of the N 2 O isotopic composition. In the last few years, the study of N<sub>2</sub> O site-specific nitrogen isotope composition has been established as a powerful technique to disentangle N<sub>2</sub> O emission pathways. This trend has been accelerated b...

Anonymous, 2012: Retraction. Urinary trypsin inhibitor reduced neointimal formation after stent implantation in minipig. Scandinavian Cardiovascular Journal 46(3): 189-189

Anonymous, 1915: Remember Your Friends. California State Journal of Medicine 13(8): 293-294

Del Mundo, F.; Echevarra, R.; Leuterio, L.; Sarcia, S., 1972: Better utilization of traditional birth attendants (hilots) in the delivery of maternal-child health services in Philippine rural communities: a pilot project (1971-72). In the Philippines, where rapid population growth strains the health facilities, there were 8866 traditional birth attendants, hilots, in 1971. In 1970 a study of 142 hilots was conducted to train them in a 5-day course in pregnancy care and evalu...

Ozbilen, M.; Adams, C.E.; Marley, J., 2012: Anticholinergic Effects of Oral Antipsychotic Drugs of Typicals Versus Atypicals Over Medium- and Long-Term Systematic Review and Meta-Analysis. Anticholinergic side-effects of antipsychotic drugs are common and can potentially impact on quality of life as well as concordance with medication. To investigate prevalence/incidence rates of anticholinergic side-effects of oral antipsychotic dr...