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Long term effects of intravenous infusion of fluorocarbon blood substitute in dogs

, : Long term effects of intravenous infusion of fluorocarbon blood substitute in dogs. Zhongguo Yao Li Xue Bao 6(4): 270-273

Biochemical and morphological changes 1 yr after iv fluorocarbon emulsions (FCE) 20 ml/kg in dogs were studied. No serious disturbances in hematology, cytogenetics, liver and kidney function were seen. The major finding was the persistence of numerous foam cells in liver, spleen, lymph nodes, lungs, kidneys and bone marrow. Most of the FC granules were engulfed by macrophages in the reticuloendothelial system. One month after iv FCE, the total number of foam cells increased rapidly, then gradually decreased, and disappeared 1 yr after iv FCE, but many FC granules existed in cells of organs especially spleen. The foam cells may be derived from reticulum cells or Kupffer's cells. There were a large number of vesicles in the cytoplasm which contained low-density granules, corresponding to FC granules, about 0.1-1.0 .mu.m in diameter. The data suggest tht FCE is inert and not toxic to the cells. There were no secondary histopathologic changes caused by FC deposition. It seems that FCE 20 ml/kg iv is rather safe in dogs.


PMID: 2945371

Other references

Kalinina, A.R.; Sadovnikov, V.B., 1992: Extracellular mechanism of the anti-tumor manifestation of LAK-supernatants. Doklady Akademii Nauk 325(2): 406-411

Mays, R.; Venero, J.A.; Davis, D.A.; Rouse, D.B.; Saoud, I.P., 2006: Nursery protocols for the rearing of the brown shrimp, Farfantepenaeus aztecus: effects of stocking density and salinity. Recreational saltwater fishing in coastal areas of the United States of America is partly dependent on the availability of live bait for anglers. One bait species commonly used is the brown shrimp, Farfantepenaeus aztecus. Three experiments were c...

Hunt, A.; Lockley, M.; White, S., 2002: Historic dinosaur quarries of the Dinosaur Ridge area. Unknown

Parupia, J.; Minshew, M.; Orsulak, P.; Keffer, J., 1993: Confirmation of amphetamine immunoassay results using the Remedi drug profiling system. Clinical Chemistry 39(6): 1234

Dehaene, J.L., 1985: Options and priorities in medical research. Verhandelingen - Koninklijke Academie Voor Geneeskunde van Belgie 47(6): 571-576

Indrák, K.; Jarosová, M.; Dusek, J.; Scudla, V.; Kapustová, M., 1988: Results of the cytogenetic examination of 54 patients with polycythemia vera. Vnitrni Lekarstvi 34(4): 322-329

Dantzer, R.; Mormede, P.; Favre, B., 1976: Fear dependent variations in continuous avoidance behavior of pigs part 2 effects of diazepam on acquisition and performance of pavlovian fear conditioning and plasma cortico steroid levels. Previously acquired continuous avoidance performance of pigs in a shuttle-box was modified by a Pavlovian fear-conditioning procedure. Diazepam (1 mg/kg) given before the Pavlovian conditioning session prevented the increase in corticosteroids and...

Raleigh, D.R.; Marchiando, A.M.; Zhang, Y.; Shen, L.; Sasaki, H.; Wang, Y.; Long, M.; Turner, J.R., 2010: Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. In vitro studies have demonstrated that occludin and tricellulin are important for tight junction barrier function, but in vivo data suggest that loss of these proteins can be overcome. The presence of a heretofore unknown, yet related, protein co...

Israël, A., 1992: The rel/NF-kappa B family of transcription factors: a novel mechanism to control gene expression. Pathologie-Biologie 40(3): 212-214

Beeckmans, J.M., 1970: The deposition of asbestos particles in the human respiratory tract. International Journal of Environmental Studies 1(1-4): 31-34