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Mass fragmentographic quantitation of ethotoin and some of its metabolites in human urine


, : Mass fragmentographic quantitation of ethotoin and some of its metabolites in human urine. Journal of Chromatography 143(2): 161-169

A method for the determination of [the anti epileptic drug] ethotoin and its p-hydroxylated and dealkylated metabolites in urine was developed. Ethotoin and the metabolites were extracted from acidified urine with ethyl acetate and silylated before injection into a combined gas chromatograph-mass spectrometer. Four partly identified metabolites were recorded, but their exact quantitation was not possible as pure reference substances were not available. The limit of sensitivity was far below the amounts of ethotoin and of its metabolites found in urine from patients treated with therapeutic doses of ethotoin.

US$19.90

PMID: 14171

DOI: 10.1016/s0378-4347(00)81821-6


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