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Measurement of histamine a quality control study

, : Measurement of histamine a quality control study. Journal of Allergy & Clinical Immunology 66(4): 295-298

The ability of various laboratories to accurately quantitate histamine in samples of plasma and buffered saline that contained known amounts of histamine was studied. Histamine was dissolved in buffered saline and in plasma and these solutions were lyophilized in glass ampules. Sealed ampules were sent to laboratories for analysis of their histamine content by 1 or more of the following methods: the double-isotope dilution enzymatic method, single-isotope enzymatic method and manual and automated fluorimetry. The same solutions were analyzed in the laboratory by the double-isotope dilution enzymatic method over 6 mo. A coefficient of variation averaging 26% was found for these samples over that period of time and the calculated values agreed with theoretical values within 12%. Twelve laboratories analyzed histamine by the double-isotope dilution enzymatic assay. The results revealed a marked variation among laboratories both for the determination of histamine in buffer and, more strikingly, for the determination of histamine in plasma. Three laboratories determined histamine by the single-isotope dilution enzymatic method and 1 reported results rather close to the standard, while the others reported results that were clearly different from the standards. Five laboratories measured histamine by automated fluorimetry and 3 by manual fluorimetry; again, there was marked variation among the results. Overall, measurements of histamine by different laboratories vary greatly. Absolute values for histamine in [human] biologic specimens in the literature must be regarded with caution.


PMID: 7419831

DOI: 10.1016/0091-6749(80)90024-x

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