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Metabolic effects of dietary adenine in rats

, : Metabolic effects of dietary adenine in rats. Nippon Nogeikagaku Kaishi 55(9): 811-816

The metabolic effects of adenine and other purines in rats were clarified. When rats were fed on a 0.25-1.00% adenine diet, the level of serum allantoin and creatinine increased progressively with increasing adenine levels. Serum urea nitrogen increased when the level of adenine was raised 0.50% or more. The body weight and food intake were decreased in rats fed on a diet containing 0.50-1.00% adenine. Rats on diets containing 1.00% of various purines other than adenine showed higher levels of serum allantoin, in the decreasing order of hypoxanthine, guanine, inosine, adenosine and guanosine. When rats were fed on a 0.75% adenine diet, a decrease was observed in urinary excretion of uric acid, creatinine and urea. Feeding an adenine diet to rats caused a rise in urinary allantoin.


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