geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mononuclear phagocyte abnormality in sarcoidosis ii. primary cultures of sarcoid granulomas


, : Mononuclear phagocyte abnormality in sarcoidosis ii. primary cultures of sarcoid granulomas. Okayama Igakkai Zasshi 99(9-10): 1137-1150

In order to clarify the role of monocytes and macrophages in the formation of sarcoid granulomas, primary cultures of sarcoid tissues were initiated with biopsied specimens from patients with sarcoidosis (6 lymph nodes and one subcutaneous nodule), and compared with primary cultures of 5 lymph nodes obtained from patients with other disorders. The number of monocytes and macrophages migrating from tissue explants was larger in sarcoid tissues than in non-sarcoid tissues. In the cultures of sarcoid tissues, the monocytes and macrophages aggregated at the second week of cultures and multinucleated giant cells was observed at the third week. However, these findings were not observed in the culture of non-sarcoid tissues. At the fourth week, the aggregated macrophages and multinucleated giant cells disappeared and fibroblasts developed. The lysozyme activity of the culture medium of sarcoid tissues was higher than that of non-sarcoid tissues, but no difference was observed in angiotensin-converting enzyme activity. These results suggest that the monocytes and macrophages in sarcoid granulomas have been activated by unknown factors and may transform to epithelioid cells constituting sarcoid granulomas.

US$29.90


Other references

Beier, M., 1938: Nachtrage und Berichtigungen zu den einzelnen Insecten-Ordnungen. In Kukenthal Handb Zool Berlin, 4: 2457-2490

Laver, K.E.; George, S.; Thomas, S.; Deutsch, J.E.; Crotty, M., 2015: Virtual reality for stroke rehabilitation. Virtual reality and interactive video gaming have emerged as recent treatment approaches in stroke rehabilitation. In particular, commercial gaming consoles have been rapidly adopted in clinical settings. This is an update of a Cochrane Review pub...

Johnson William C., 1987: Geomorphology and paleoenvironmental reconstructions of the North Cove Paleoindian site, Nebraska. Abstracts with Programs - Geological Society of America 19(7): 719

Trottier, C.; Repérant, J.; Miceli, D., 1995: Anatomical evidence of a retino-thalamo-hippocampal pathway in the pigeon (Columba livia). The aim of the present study was to demonstrate the existence of a retino-thalamo-hippocampal pathway in the pigeon and, more specifically, to identify its thalamic relay (n. superficialis parvocellularis: SPC). Fluorescence axonal tracing techniq...

Ramisse, J.; Asso, J.; Hassani, A.; Anane, O.; Jemli, J., 1978: Cell culture of sheep-pox virus: application to vaccine preparation and testing of immunity. Sheep pox is not a serious problem in Tunisia because of large-scale annual vaccination with inactivated vaccine. The virulent Zaghouan strain, which is used to produce the inactivated vaccine, did not show attenuation after ten passages in cell c...

Crispino, J.D.; Orkin, S.H., 2002: The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. With the increasing popularity of the yeast two-hybrid screen, a large number of protein-protein interactions have been identified. In many cases, single proteins have been found to associate with a large number of cofactors. For example, the hema...

El-Taher, A., 2011: Rare earth elements content in geological samples from eastern desert, Egypt, determined by instrumental neutron activation analysis. Twenty representative geological samples (tonalite, granodiorite, adamellite, syenogranite, rapakivi syenogranite, alkali feldspar granite and monzogranite) were collected from G. Kattar area in Eastern Desert, Egypt, for analysis by instrumental...

Asadollahi-Baboli, M., 2016: In silico evaluation, molecular docking and QSAR analysis of quinazoline-based EGFR-T790M inhibitors. Mutated epidermal growth factor receptor (EGFR-T790M) inhibitors hold promise as new agents against cancer. Molecular docking and QSAR analysis were performed based on a series of fifty-three quinazoline derivatives to elucidate key structural and...

Soldevilla, M.M.; Villanueva, H.; Pastor, F., 2016: Aptamers: A Feasible Technology in Cancer Immunotherapy. Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity. Aptamers normally show affinities comparable to or higher than that of antibo...

Spooner, G.M., 1940: An account of Marinogammarus gen nov , with a description of a new species, M pirloti. One of Schellenberg's (1937) subgenera of Gammarus F. is raised to generic status, and a full description, with detailed illustrations, is given of the 6 spp. which are to be included in it. One of these, Marinogammarus pirloti, is descr. for...