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Morphine and methadone impact on human phagocytic physiology


, : Morphine and methadone impact on human phagocytic physiology. International Journal of Immunopharmacology 7(6): 865-874

Human subjects submitted to treatment with morphine show a severe depression of phagocytosis, killing properties and superoxide production both of their polymorphonuclear leukocytes and monocytes. Polymorphonuclear leukocyte adherence, chemotaxis, random migration, myeloperoxidase content, lysozyme content and lymphocyte Rosette E formation were poorly influenced. Methadone-treated subjects show a similar effect at phagocytic level but far less evident. These results confirm those previously found in animals and reinforce the evidence of a depressive role of morphine on phagocytic physiology.

US$19.90

PMID: 3000961

DOI: 10.1016/0192-0561(85)90049-9


Other references

Frigerio, F.; Coda, A.; Pugliese, L.; Lionetti, C.; Menegatti, E.; Amiconi, G.; Schnebli, H.P.; Ascenzi, P.; Bolognesi, M., 1992: Crystal and molecular structure of the bovine alpha-chymotrypsin-eglin c complex at 2.0 A resolution. The crystal structure of the complex between bovine alpha-chymotrypsin and the leech (Hirudo medicinalis) protein proteinase inhibitor eglin c has been refined at 2.0 A resolution to a crystallographic R-factor of 0.167. The structure of the compl...

Gielens, C.; D.G.est, N.; Xin, X.Q.n, 1997: Evidence for a cysteine-histidine thioether bridge in functional units of molluscan haemocyanins and location of the disulfide bridges in functional units d and g of the bC-haemocyanin of Helix pomatia. European Journal of Biochemistry 248: 9-88

Spasova, M.; Mespouille, L.; Coulembier, O.; Paneva, D.; Manolova, N.; Rashkov, I.; Dubois, P., 2009: Amphiphilic poly(D- or L-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) block copolymers: controlled synthesis, characterization, and stereocomplex formation. Novel well-defined amphiphilic poly(D-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) (PDLA-b-PDMAEMA) and poly(L-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) (PLLA-b-PDMAEMA) copolymers were obtained. The synthesis strategy con...

Mewburn, F.H., 1929: The Life and Work of Dr. George A. Kennedy. Canadian Medical Association Journal 21(3): 327-330

Sakamoto, T.; Moriya, M.; Haga, Y.; Takahashi, T.; Shibata, T.; Okamoto, O.; Nonoshita, K.; Kitazawa, H.; Hidaka, M.; Gomori, A.; Iwaasa, H.; Ishihara, A.; Kanatani, A.; Fukami, T.; Gao, Y-Duo.; Macneil, D.J.; Yang, L., 2009: Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists. A series of spiroindoline-3,4′-piperidine derivatives were synthesized and evaluated for their binding affinities and antagonistic activities at Y5 receptors. Potent Y5 antagonists were tested for their oral bioavailabilities and brain penet...

Marcoux J., 1983: Antalya korfezi bati kiyi siradaglarinin jeolojisi--Geology of the western Antalya Bay coast ranges. 1; Pages 18-19:

Fajardo Ortiz, G., 1973: Administration of medical care. Administrative development of medical organizations. Salud Publica de Mexico 15(6): 909-915

Anand, R.; Ethunandan, M.; Ramchandani, P.; Brennan, P., 2006: Perils of football goalkeepers. British Journal of Oral & Maxillofacial Surgery 45(7): 603-604

Gail, M.M., 1963: Spring phytoplankton in the southeastern part of the Tatar Strait. This study is the result of correlating data from 1949-1955. During this period 1094 specimens (382 bathometric, the remainder net) were collected at 803 stations located 800 m to 75 m from the shore. A 0-50-meter area showed more active biologica...

Ahmed, N.; Milne, P.J.; Harris, S.G., 1975: Electrocardiographic data compression via orthogonal transforms. IEEE Transactions on Bio-Medical Engineering 22(6): 484-487