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Morphine and methadone impact on human phagocytic physiology

, : Morphine and methadone impact on human phagocytic physiology. International Journal of Immunopharmacology 7(6): 865-874

Human subjects submitted to treatment with morphine show a severe depression of phagocytosis, killing properties and superoxide production both of their polymorphonuclear leukocytes and monocytes. Polymorphonuclear leukocyte adherence, chemotaxis, random migration, myeloperoxidase content, lysozyme content and lymphocyte Rosette E formation were poorly influenced. Methadone-treated subjects show a similar effect at phagocytic level but far less evident. These results confirm those previously found in animals and reinforce the evidence of a depressive role of morphine on phagocytic physiology.


PMID: 3000961

DOI: 10.1016/0192-0561(85)90049-9

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