geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neurobehavioral effects of permethrin are associated with alterations in regional levels of biogenic amine metabolites and amino acid neurotransmitters


, : Neurobehavioral effects of permethrin are associated with alterations in regional levels of biogenic amine metabolites and amino acid neurotransmitters. Neurotoxicology 7(1): 143-153

Oral administration of 120 or 240 mg/kg permethrin produced dose- and time-related tremor in rats with the peak effect occurring 5 hrs after dosing. Subsequent experiments done 5 hrs postdosing found that 45 to 180 mg/kg permethrin produced dose-related increases in rectal temperature and enhanced responsiveness to an acoustic stimulus. Tremor was detected at 90 and 180 mg/kg. Neurochemical analyses of regional biogenic amines and their metabolites and amino acids 5 hrs after 90 or 180 mg/kg indicated that 5-HIAA levels were increased in the hypothalamus (HYP), brain stem (BS), hippocampus (HPC), and striatum (STR); 5-HT was not affected. MHPG was increased in the HYP and BS, while NE was decreased at the high dose only. DOPAC and HVA were increased in the STR after 90 and 180 mg/kg, while DA was not affected. Aspartate levels were increased in the BS and STR; glutamate was increased in the BS. Taurine, glutamine, glycine, and GABA were not affected. A time-course analysis of neurochemical changes 2, 5, 12, and 24 hrs postdosing indicated that 5 hrs was the time of peak effect for permethrin. Permethrin-induced tremor and hyperthermia were significantly correlated with dose- and time-related changes in MHPG, 5-HIAA, and ASP.

US$29.90

PMID: 2872638


Other references

Richardson C.C., 1992: Annual review of biochemistry vol 61. This volume contains 35 monographs on diverse topics in recent biochemical research. Also included is a brief autobiography of E. P. Kennedy. The monographs are all highly detailed, heavily referenced, literature reviews. The text closes with indi...

Béland, P.; Krupin, O.; Berini, P., 2015: Selective detection of bacteria in urine with a long-range surface plasmon waveguide biosensor. Experimentation demonstrates long-range surface plasmon polariton waveguides as a useful biosensor to selectively detect gram negative or gram positive bacteria in human urine having a low concentration of constituents. The biosensor can detect ba...

Witte, Jurgen, 1940: Zur Frage der Indolreaktion. Investigation of 113 indol-positive and 21 indol-negative organisms shows that the method using the Frieber medium is satisfactory but the Hottinger broth made from ox testes is better than other media recommended. The reagent of Kovacs is an impr...

Shor, N.A.; Zhadanov, V.I., 1998: Indications for and prognostication of results of lumbar sympathectomy in patients with obliterating atherosclerosis of the lower limbs with chronic critical ischemia. The instrumental methods of investigation data, permitting to estimate the regional hemodynamics state in affected extremity, was used for the lumbar sympathectomy (LS) result prognosis in patients with obliterating atherosclerosis of the lower ex...

Courtney, LA.; Couch, JA., 1981: Aspects of the host-commensal relationship between a palaemonid shrimp Pontonia domestica and the pen shell Atrina rigida. Northeast Gulf Science, 51: 49-54

Pell, A.; Schofield, P.S.one, W., 1993: Rates of digestion of feeds measured in vitro with computers. Proceedings 4-81

Zhang D.; E.A., 1990: Ultrastructural study of the effect of angelica sinensis olic diels on the ovary of mice radiated by cobalt 60 ray. 228 adult female mice were radiated by Co-rad:100 of them were injected by injection Angeeica sinensis (Olic) Diels intraperitoneally as experiment group, 96 of them served as experiment control gorup, and 28 normal mice as normal control group. T...

Tsou, P.M., 2001: Mislabelling the articles, and then injecting strong bias against lumbar provocation discography as a diagnostic tool. Spine 26(8): 994-996

Mallidis, C.; Wistuba, J.; Bleisteiner, B.; Damm, O.S.; Gross, P.; Wübbeling, F.; Fallnich, C.; Burger, M.; Schlatt, S., 2011: In situ visualization of damaged DNA in human sperm by Raman microspectroscopy. Beyond determining the percentage of damaged sperm, current methods of DNA assessment are of limited clinical utility as they render the sample unusable. We evaluated Raman microspectroscopy, a laser-based non-invasive technique that provides deta...

Krustins, E.; Kravale, Z.; Buls, A., 2014: Mounier-Kuhn syndrome or congenital tracheobronchomegaly: a literature review. Mounier-Kuhn syndrome or congenital tracheobronchomegaly is a chronic airway condition which for currently unknown reasons mostly affects males. It is commonly overlooked on conventional chest X-rays, and is considered to be rare, but the prevalen...