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Observations on the retinal pigment epithelium and retinal macrophages in experimental retinal detachment

, : Observations on the retinal pigment epithelium and retinal macrophages in experimental retinal detachment. British Journal of Ophthalmology 61(9): 564-572

After experimental retinal detachment in rabbits macrophages are a prominent feature in the subretinal space or within the retina. Two sources for these macrophages were identified [by EM]. The retinal pigment epithelium (RPE) may undergo metaplasia and actively bud; the evolving macrophage was then formed by a vitreal protrusion of the cytoplasm of an RPE cell which was nipped off by lateral protrusions from adjacent cells. In addition, in regions of RPE proliferation, blood-borne cells were found in Bruch's membrane and among the mass of proliferated RPE cells, suggesting that blood-borne cells may pass from the choroidal circulation through Bruch's membrane and the RPE layer.


PMID: 921919

DOI: 10.1136/bjo.61.9.564

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