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Oral contraceptives and hepatocellular carcinoma


, : Oral contraceptives and hepatocellular carcinoma. British Medical Journal 292(6532): 1355-1357

A series of 26 white women aged under 50 who developed hepatocellular carcinoma in a non-cirrhotic liver were studied for the possible role of oral contraceptives. Eighteen of the women had used the "pill" for a median of eight years. Over 1300 women whose use of the pill had been determined in another study served as controls. Patients and controls were divided into five age and four calendar groups and the relative risks associated with oral contraceptives calculated by multivariate analysis. Short term use of the pill was not associated with an increased risk of tumour development; nevertheless, use for eight years or more was associated with a 4.4-fold increased risk (p less than 0.01). When patients with markers of hepatitis B virus infection were excluded the relative risk was 7.2 (p less than 0.01). In both instances the absolute risk for developing hepatoma remained low.

US$19.90

PMID: 3011185

DOI: 10.1002/1097-0142(19820115)49:2<407::aid-cncr2820490233>3.0.co;2-e


Other references

Yeakley J.A.; Swank W.T., 1998: Relative importance of topographic and soil properties controls on soil moisture in the Southern Appalachian Mountains. Eos, Transactions, American Geophysical Union 79(45, Suppl

Toucanne, S.; Zaragosi, S.; Eynaud, F.; Bourillet, J.F.; Lericolais, G.; Gibbard, P.L., 2011: Causes, consequences and chronology of large-magnitude palaeoflows in middle and late Pleistocene river systems of northwest Europe; discussion. Earth Surface Processes and Landforms 36.10

Ulrich G.E. (investigator), 1981: Colorado Plateau margin in central Arizona. U S

Charamis, J.; Tsamparlakis, J.; Scouras, J.; Doris, M.; Vassiliou, G., 1976: Ophthalmologic manifestations of intracranial arterial aneurysms. Bulletins et Memoires de la Societe Francaise D'ophtalmologie: 213-218

Chen WanRu; Chen ZengHong; Dong DiaoVa, 1995: The ecological relation between the growth of Termitomyces albuminosus and Termitosphaeria duthiei and substrates. Mycelial growth of Termitomyces albuminosus and Termitosphaeria [Termitosphaera] duthiei (a sporodochia stage of T. albuminosus) during culture on basal medium was slow. Growth was promoted by the addition of aconitic, fumaric and citric acid. For...

Marianovich, A.; Kushich, R.; Rosich, N., 1984: Hazards of drug use in the perinatal period. Pediatriia: 49-52

Fumarola, D.; Munno, I.; Marcuccio, C.; Miragliotta, G., 1986: Endotoxicity associated with the Lyme disease Borrelia: recent findings. The endotoxicity of Borrelia burgdorferi, the causative agent of Lyme Disease, a tick-borne spirochetosis, was studied using Limulus assay and pyrogen test in rabbit. Some suspensions of Ixodes ricinus and Ixodes dammini associated Borrelia were a...

Strand, F.; Humphreys, K.; Eriksson, M.; Li, J.; Andersson, T.M.L.; Törnberg, S.; Azavedo, E.; Shepherd, J.; Hall, P.; Czene, K., 2016: Longitudinal fluctuation in mammographic percent density differentiates between interval and screen-detected breast cancer. NlmCategory="UNASSIGNED">Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mam...

Hirschhorn, K.; Kolodny, R.L.; Hashem, N.; Bach, F., 1963: Mitogenic action of phytohaemagglutinin. Lancet 2(7302): 305-306

Olai, L.; Omne-Pontén, M.; Borgquist, L.; Svärdsudd, K., 2006: Prognosis assessment in stroke patients at discharge from hospital. Background: accurate prognostic assessments of need of help, health and dwelling situation in stroke patients are important for patient management, rehabilitation, discharge planning, and for providing reliable information to patients and their r...