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Oral glucose tolerance test and insulin sensitivity in low insulin responders

, : Oral glucose tolerance test and insulin sensitivity in low insulin responders. Acta Endocrinologica 104(1): 77-84

Oral and i.v. glucose tolerance, insulin response to i.v. and oral glucose load as well as insulin sensitivity were evaluated in 58 low insulin responders. They were selected from a group of 226 healthy subjects with normal fasting blood glucose and normal i.v. glucose tolerance test on the basis of a low insulin response during a standardized glucose infusion test (GIT). The insulin response to GIT was analyzed by parameter identification in a mathematical model (parameter KI). Insulin sensitivity was also measured by computer analysis of GIT (parameter KG) and, in a limited group of subjects, by a somatostatin infusion test. Thirty-three low insulin responders had normal OGTT [oral glucose tolerance test], whereas 5 demonstrated borderline-1, 16 borderline-2, and 4 decreased OGTT. The first group of subjects demonstrated normal or enhanced insulin sensitivity. Borderline and decreased OGTT, in most instances, was accompanied by decreased insulin sensitivity, implying that a subgroup of low insulin responders exhibited signs of both impaired insulin response to glucose and insulin resistance. Since these defects characterize manifest type-2 diabetes, these subjects possibly may run a high risk to develop this type of diabetes. Low insulin response in combination with increased insulin sensitivity may reflect adaptation of the secretory capacity of B-cells to the need of insulin.


PMID: 6137926

DOI: 10.1530/acta.0.1040077

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