+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Partial reversal of anti cholinergic amnesia by choline chloride

, : Partial reversal of anti cholinergic amnesia by choline chloride. Life Sciences 29(13): 1317-1324

Young adult male humans (207) were given tests of memory and mood after receiving choline chloride plus scopolamine, placebo plus scopolamine and 2 placebos on separate days in randomized order. Scopolamine caused a marked impairment in performance on a verbal learning task. Pretreatment with choline caused a small but significant decrease in this impairment and partially reversed the mood changes produced by scopolamine. Choline apparently enhanced cognition under conditions of cholinergic blockade. This is consistent with preclinical data indicating that cholinergic neurons are most sensitive to precursor availability when they are firing rapidly.


PMID: 7289784

Other references

Sudo, A.; Kato, K.; Kobayashi, K.; Tohya, Y.; Akashi, H., 2008: Susceptibility of Plasmodium falciparum cyclic AMP-dependent protein kinase and its mammalian homologue to the inhibitors. Cyclic AMP-dependent protein kinase (protein kinase A, PKA) is a key element in many cell signaling pathways. An essential role of Plasmodium falciparum PKA (PfPKA) activity was reported in the intraerythrocytic growth of the malaria parasite. How...

Ashley, B.C.; Birchfield, P.T.; Chamberlain, B.V.; Kotwal, R.S.; McClellan, S.F.; Moynihan, S.; Patni, S.B.; Salmon, S.A.; Au, W.W., 2005: Health concerns regarding consumption of irradiated food. Food irradiation is being promoted as a simple process that can be used to effectively and significantly reduce food-borne illnesses around the world. However, a thorough review of the literature reveals a paucity of adequate research conducted to...

Mclachlan, R., 1875: A sketch of our present knowledge of the Neuropterons Fauna of Japan excluding Odonata and Trichoptera. About 45 species enumerated, many of which are new, and are here referred to in their proper places. .Leptopanorpa, p. 187. Differs from Panorpa by the extreme slenderness of all its parts; the rostrum exceedingly long, the three terminal segments...

Luzhnikov E.A.; Gol'din M.M.; Strakhova N.M.; Suslova I.M.; Kurilkin Y.A.; Ivanova G.V., 1982: Preparation of hemo sorbent. Farmatsiya (Moscow) 31(1): 73-74

Anonymous, 1992: Proceedings of the IIIrd International Symposium on Schistosomiasis and the IIIrd National Meeting on Schistosomiasis. Recife, Brazil, 20-25 October 1991. Memorias do Instituto Oswaldo Cruz 87 Suppl 4: 1-368

Tellez Duarte Miguel Agustin; Helenes Escamilla J., 2000: Caracteristicas tafonomicas en capas de conchas de moluscos en la formacion Sepultura (Paleoceno), Baja California, Mexico--Taphonomic characteristics in molluscan shell beds at Mesa La Sepultura (Paleocene), Baja California, Mexico. Memorias - Reunion Internacional Sobre Geologia de la Peninsula de Baja California = International Meeting on Geology of the Baja California Peninsula 5: 85

Perzin, K.H.; Lattes, R., 1972: Papillary adenoma of the nipple (florid papillomatosis, adenoma, adenomatosis). A clinicopathologic study. Cancer 29(4): 996-1009

Skutsch, J.C., 1991: Small scheme design and MIDAS (Minor Irrigation Design Aid Software). The need for technical assistance to irrigation design staff in developing countries in the form of computer-aided design is discussed. If the schemes are small and are numerous and/or remote, design capability may be stretched. The MIDAS software...

Badley, E.M.; Thompson, R.P.; Wood, P.H., 1978: The prevalence and severity of major disabling conditions--a reappraisal of the government social survey on the handicapped and impaired in Great Britain. This paper re-examines the data gathered for the Government Social Survey on the Handicapped and Impaired in Great Britain. The underlying cause of disablement is considered in conjunction with severity and prevalence. When these are taken togethe...

Saiz, C.; Wipf, P.; Manta, E.; Mahler, G., 2009: Reversible thiazolidine exchange: a new reaction suitable for dynamic combinatorial chemistry. New dynamic combinatorial libraries (DCLs) were generated using the reversible aminothiol exchange reaction of thiazolidines and aromatic aldehydes. The reaction proceeded in aqueous buffered media at pH 4 and room temperature to generate thermody...