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Partial reversal of anti cholinergic amnesia by choline chloride


, : Partial reversal of anti cholinergic amnesia by choline chloride. Life Sciences 29(13): 1317-1324

Young adult male humans (207) were given tests of memory and mood after receiving choline chloride plus scopolamine, placebo plus scopolamine and 2 placebos on separate days in randomized order. Scopolamine caused a marked impairment in performance on a verbal learning task. Pretreatment with choline caused a small but significant decrease in this impairment and partially reversed the mood changes produced by scopolamine. Choline apparently enhanced cognition under conditions of cholinergic blockade. This is consistent with preclinical data indicating that cholinergic neurons are most sensitive to precursor availability when they are firing rapidly.

US$29.90

PMID: 7289784


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