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Peptic ulcer disease in children: etiology, clinical findings, and clinical course

, : Peptic ulcer disease in children: etiology, clinical findings, and clinical course. Pediatrics 82(3 Pt 2): 410-414

The records of all children with peptic ulcer disease at the Hospital for Sick Children were retrospectively evaluated, excluding neonates, throughout a 5-year period. Only cases with a definite ulcer crater identified either at endoscopy or at surgery were included. There were 36 patients, 20 boys and 16 girls. Duodenal ulcers were more common than gastric ulcers (2.8:1). Ages ranged from 3 months to 17 years, with a mean age of 10 years. Patients were reviewed with respect to etiology of peptic ulcer disease, age when first examined, initial symptoms, and clinical course. Patients were divided into two groups, those with primary (n = 19) and those with secondary (n = 17) peptic ulcer disease. All peptic ulcers in patients younger than 10 years of age were secondary in nature. Secondary ulcers occurred generally in association with a severe underlying illness (11/17), and many ulcers necessitated emergency surgery because of perforation and/or severe hemorrhage (8/17). None of these patients had chronic or recurrent symptoms. In contrasts, in children with primary peptic ulcer disease, initial symptoms were more benign. Most patients had abdominal pain and only one required emergency surgery. Children with primary duodenal ulcer disease had a high incidence of recurrent sysmptoms (67%), however, with surgery for intractable disease necessitated in 40%. Single-contrast barium meals were found to be unreliable in establishing a diagnosis of peptic ulcer disease, particularly cases of gastric ulcer disease.


PMID: 3405676

Other references

Boaretto, A.E.; Rosolem, C.A.; Chitolina, J.C., 1983: Comparison between phosphorus fertilizers in soyabean and wheat crops. Effects of application of 2 fused phosphates (16 and 10% P2O5), alone or in mixture with triple superphosphate with or without Ca, were studied on soyabean cv. Santa Rosa, a subsequent crop of wheat cv. IAC-5 and a 2nd soyabean crop in a pot trial...

Merritt J.E.; Armstrong W.P.; Hallam T.J.; Jaxa Chamiec A.; Jacob R.; Leigh B.K.; Moores K.E.; Rink T.J., 1990: Skf 96365 inhibits receptor mediated calcium entry in human platelets neutrophils and endothelial cells. Nishizuka, Y , M Endo And C Tanaka (Ed ) Advances in Second Messenger And Phosphoprotein Research, Vol 24 The Biology And Medicine Of Signal Transduction; 7th International Conference on Cyclic Nucleotides, Calcium And Protein Phosphorylation, Kobe, Japan, October 8-13, 1989 Xxxiii+750p Raven Press: New York, New York, Usa Illus 724

Mende, K.; Petoukhova, O.; Nowak, G., 1998: CDNA cloning and characterization of a potent thrombin inhibitor from the assassin bug Dipetalogaster maximus. Annals of Hematology 76(SUPPL 1): A7

Llewellyn, L.E., 2006: Saxitoxin, a toxic marine natural product that targets a multitude of receptors. Saxitoxin (STX) was discovered early last century and can contaminate seafood and drinking water, and over time has become an invaluable research tool and an internationally regulated chemical weapon. Among natural products, toxins obtain a unique...

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Pacher, Martina., 2000: Taphonomic studies of the cave bear discoveries from Schwabenreith Cave near Lunz am See in Lower Austria Taphonomische Untersuchungen der Hoehlenbaeren-Fundstellen in der Schwabenreith-Hoehle bei Lunz am See Niederoesterreich. Schwabenreith-Cave is located near Lunz am See in the western part of Lower Austria. The entrance lies at 959m above sea1evel. This study is based on rich cave bear material recovered during excavation campaigns carried out by the Institute of Pal...

Koller, A., 1952: The effect of adrenocorticotropic hormone (AGTH) on the vaginal cycle of the rat. Daily injections of 5 nag. ACTH over a period of 28 days led to oestrus inhibition and reduction in the number of oestrous periods, or to persistent oestrus, in mature rats which had previously shown regular cycles. G. E. A.

Kaneko, Y., 1978: Studies on the culture of human cancer cells--establishment of human rectal cancer cell lines and their production of carcinoembryonic antigen (CEA). Igaku Kenkyu. Acta Medica 48(4): 298-321

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