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Peptic ulcer disease in early infancy: clinical presentation and roentgenographic features

, : Peptic ulcer disease in early infancy: clinical presentation and roentgenographic features. Acta Paediatrica Scandinavica 69(6): 753-760

Sixteen infants under 11 wk of age developed documented peptic ulcer disease involving the stomach, duodenum or pylorus during an 8-yr period in a Newborn Intensive Care Unit at the University of Minnesota Hospital, Minneapolis, Minnesota. The precipitous onset of gastrointestinal bleeding and/or perforation commonly associated with ulcer disease in early infancy was present in only 7 (44%) of the 16 patients. The remaining 9 infants (56%) presented with recurrent emesis, a presentation of peptic ulcer disease rarely described in the 1st wk of life. Contrast radiography was used to demonstrate a definite ulcer crate in 13 of these patients. Two had their ulcers diagnosed at surgery and 1 by endoscopy. Radiographic demonstration of pylorospasm and/or gastric retention was often associated with ulcer craters located in the pyloric channel or gastric antrum. Only 2 patients required surgery for massive bleeding and perforation. The remainder were successfully managed medically using orogastric suction, antacids and gradual resumption of milk feedings. There were no deaths within the population attributable to peptic ulcer disease.


PMID: 7211360

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