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Pharmacokinetic and clinical studies of the effectiveness of cefuzonam on obstetric and gynecologic infections

, : Pharmacokinetic and clinical studies of the effectiveness of cefuzonam on obstetric and gynecologic infections. Japanese Journal of Antibiotics 40(5): 1001-1006

Cefuzonam (CZON, L-105), a new semisynthetic cephem antibiotic, was studied in the field of obstetrics and gynecology, pharmacokinetically and clinically. Following is a summary of the results. 1. Concentrations of CZON in serum and genital organs following intravenous drip infusion of 1 g of the drug over 60 minutes were measured. Samples were taken during 40 to 190 minutes after the end of the infusion. Ratios of concentrations of the drug transferred into genital organs to the concentration in the cubital venous serum were 0.5 to 1.5 in many cases. Levels of the drug in the genital organs examined well exceeded MICs for common causative organisms in obstetric and gynecologic infections. 2. Therapeutic effects of 1 g or 2 g of CZON by drip infusion twice daily were evaluated in 8 patients. Overall clinical efficacy was 62.5% (5/8). No side effects of abnormal laboratory findings due to the drug were noted. The results suggest that CZON is a useful antibiotic for obstetric gynecologic infections.


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