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Pharmacokinetic and clinical studies of the effectiveness of cefuzonam on obstetric and gynecologic infections


, : Pharmacokinetic and clinical studies of the effectiveness of cefuzonam on obstetric and gynecologic infections. Japanese Journal of Antibiotics 40(5): 1001-1006

Cefuzonam (CZON, L-105), a new semisynthetic cephem antibiotic, was studied in the field of obstetrics and gynecology, pharmacokinetically and clinically. Following is a summary of the results. 1. Concentrations of CZON in serum and genital organs following intravenous drip infusion of 1 g of the drug over 60 minutes were measured. Samples were taken during 40 to 190 minutes after the end of the infusion. Ratios of concentrations of the drug transferred into genital organs to the concentration in the cubital venous serum were 0.5 to 1.5 in many cases. Levels of the drug in the genital organs examined well exceeded MICs for common causative organisms in obstetric and gynecologic infections. 2. Therapeutic effects of 1 g or 2 g of CZON by drip infusion twice daily were evaluated in 8 patients. Overall clinical efficacy was 62.5% (5/8). No side effects of abnormal laboratory findings due to the drug were noted. The results suggest that CZON is a useful antibiotic for obstetric gynecologic infections.

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Other references

Lindblad B.; Burkel W.E.; Wakefield T.W.; Graham L.M.; Stanley J.C., 1988: Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production. The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF1.alpha. and TxB2 was quan...

Valdizán, J.R.; Mercado, E.; Mercado-Undanivia, A., 2007: Clinical variability and characteristics of attention deficit hyperactivity disorder in girls. Attention deficit hyperactivity disorder (ADHD) is a neurobiological condition essentially characterised by inattention, hyperactivity and impulsiveness, and has a prevalence of around 5%. Because it is a biological disorder, both boys and girls w...

Klisenko, M.A.; Pis'mennaia, M.V.; Novitskaia, L.P.; Brodskaia, N.M., 1967: Determination of Phthalophos and Phozalon in the air. Gigiena i Sanitariia 32(8): 67-70

Furuno, T.; Nagadomi, W.; Goto, T., 1975: Structure of the interface between wood and synthetic polymer. VI. Separation of cell-walls from wood-polymer composite (WPC) by ultrasonic method and existence of polymer in the wood cell-wall. [Cf. FA 36, 4288] Specimens of sapwood of Chamaecyparis obtusa were impregnated with dioxan or methanol solutions of methyl methacrylate, which was polymerized by thermal treatment. Polymer present in the lumina was removed by ultrasonic treatment...

Doong, R.L.; Ganson, R.J.; Jensen, R.A., 1993: Plastid-localized 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DS-Mn): the early pathway target of sequential feedback inhibition in higher plants. DS-Mn was extracted from spinach leaves, potato tubers and tobacco cell cultures. A procedure for isolation of DS-Mn in the labile, inactive state is given. The enzyme was stimulated by Mn2+, had relatively high affinity for erythrose-4-phosphate...

Santero E.; Hoover T.; Kustu S., 1990: Involvement of ihf in gene expression from the nif h promoter of klebsiella pneumoniae. Gresshoff, P M , Et Al (Ed ) Nitrogen Fixation: Achievements And Objectives; 8th International Congress on Nitrogen Fixation, Knoxville, Tennessee, Usa, May 20-26, Xix+869p Routledge, Chapman And Hall: New York, New York, Usa; London, England, Uk Illus 579

Martinesi, L.; Albertini, E.; Gori, A., 1964: Experimental Analysis Of Arteriopathic Pathogenetic Periods In Chemically Induced Lathyroid Syndromes. Rivista di Anatomia Patologica E di Oncologia 25: 40-51

Peters, H.B., 1938: Der Kara katschan-Hund. Zeitschrift fuer Hundeforschung Leipzig, 13: 55-62

Heins, R.D.; Wilkins, H.F., 1979: The influence of photoperiod on lateral shoot development of carnation. Experiments were performed on carnation's to determine the effect of light quality used to provide long days on lateral shoot production. Treatments were natural daylength; short days (8h); or additional light from 2200h to 0200h with cool wh...

Pałgan, K.; Bartuzi, Z.; Chrzaniecka, Eżbieta., 2017: ABO blood groups, Rhesus factor, and anaphylactic reactions due to Hymenoptera stings. Numerous publications indicate that the prevalence of some infectious, neoplastic and immunological diseases are associated with ABO blood groups. The aim of this study was to verify whether ABO and Rh blood groups are associated with severe anaph...