geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pharmacokinetics of methotrexate and 7 hydroxymethotrexate after high dose 33.6 g per square meter methotrexate therapy


, : Pharmacokinetics of methotrexate and 7 hydroxymethotrexate after high dose 33.6 g per square meter methotrexate therapy. Pediatric Hematology and Oncology 3(2): 127-134

We have measured MTX and 7-OH-MTX in plasma and urine samples from a 9-year-old boy treated with six consecutive 24-h IV high-dose MTX courses (33.6 g/m2) after a relapse of ALL. The between-course pharmacokinetics of MTX and 7-OH-MTX were found to be highly reproducible. Both MTX and 7-OH-MTX elimination followed a biphasic curve, initial half-lives (t1/2(.alpha.)) being 2.86 .+-. 0.44 h and 5.14 .+-. 0.46 h (mean .+-. SD) and second-phase biological half-lives (t1/2(.beta.) being approximately 18 and 16 h, respectively. The apparent volume of distribution for MTX was 0.8 L/kg, whereas the corresponding value for 7-OH-MTX was threefold less. Since clearance of MTX was within the range reported for lower doses, the data suggest that MTX pharmacokinetics are not dose-dependent up to 33.6 g/m2.

US$29.90


Other references

Pensaert, M.; Labarque, G.; Favoreel, H.; Nauwynck, H., 2005: Aujeszky's disease vaccination and differentiation of vaccinated from infected pigs. In this paper, the use of a glycoprotein E (gE)-deleted vaccine to eradicate Aujeszky's disease virus (ADV) or pseudorabies virus in swine is described. In regions where there is a dense population of swine, ADV is highly prevalent and intens...

Gourrier E.; Lamour C.; Feldmann D.; Bensman A., 1991: Early tubular lesions due to lead poisoning in children. Archives Francaises de Pediatrie 48(10): 685-689

Fontana, M.; Banypersad, S.M.; Treibel, T.A.; Abdel-Gadir, A.; Maestrini, V.; Lane, T.; Gilbertson, J.A.; Hutt, D.F.; Lachmann, H.J.; Whelan, C.J.; Wechalekar, A.D.; Herrey, A.S.; Gillmore, J.D.; Hawkins, P.N.; Moon, J.C., 2016: Differential Myocyte Responses in Patients with Cardiac Transthyretin Amyloidosis and Light-Chain Amyloidosis: A Cardiac MR Imaging Study. Radiology 277(2): 388-397

Aghakhanyan, G.; Lupi, G.; Frijia, F.; Hlavata, H.; Lombardo, F.; D.C.ri, S.; Canapicchi, R.; Vannozzi, R.; Montanaro, D., 2014: Delayed post-traumatic fronto-ethmoidal sinus mucocele evaluated with short and long TE MR spectroscopy. Mucoceles are slow-growing, benign, expansile, mucoid-filled masses developing after obstruction of the sinus ostium. Late post-traumatic mucoceles are relatively rare entities and the literature is limited to single case reports. We describe an u...

Johnson, F.P.; Bollman, J.L.; Swenson, W.M.; Nesseler, I.C., 1964: Clinical Study Of Nonbarbiturate Sedative. Insomnia is a common complaint of variable severity. Among a selected group of 20 institutionalized women the hypnotic effect of ethchlorvynol (Placidyl) was found superior to that of a matching placebo. The hypnotic effect of the placebo was also...

Busey, P., 1971: Sorghum pachytene karyotypes. A wide range of Sorghum bicolor germplasm was studied, including wild, weedy and cultivated types, several of which were from remote regions of Africa. Most of the collections proved unsuitable for pachytene chromosome measurements. Of those which...

Pernot, C., 1984: Association of a sinus venosus-type interatrial communication and an obstructive myocardiopathy. Archives des Maladies du Coeur et des Vaisseaux 77(9): 1078-1078

Koninck, R., 1986: The peasantry as the territorial instrument of the state: the case of Malaysia. Attempts at controlling a pioneering peasantry have been closely linked to the history of state power in South East Asia. While consolidating its territorial hold, through monitoring the extension and the intensification of the agricultural sector...

Lin, P.J.C.; Tam, Y.Yi.C.; Hafez, I.; Sandhu, A.; Chen, S.; Ciufolini, M.A.; Nabi, I.R.; Cullis, P.R., 2013: Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA. The in vivo gene silencing potencies of lipid nanoparticle (LNP)-siRNA systems containing the ionizable cationic lipids DLinDAP, DLinDMA, DLinKDMA, or DLinKC2-DMA can differ by three orders of magnitude. In this study, we examine the uptake and in...

Lee, S.J.; Park, K.H., 2000: Ultrasonic energy in endoscopic surgery. The Harmonic Scalpel made by Ultracision is a system for endoscopic cutting. The energy source is vibration. The power box is attached to a forceps or blade, and the vibrational frequency of the blade approaches 55,500 cycles/second. This causes a...