+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pharmacokinetics of oral pramiracetam in normal volunteers

, : Pharmacokinetics of oral pramiracetam in normal volunteers. Journal of Clinical Pharmacology 25(4): 291-295

The pharmacokinetics of pramiracetam, a new, investigational, cognition activator, were assessed in normal male volunteers as part of a clinical tolerance study. In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (+/- SD) peak plasma concentrations of the four dose groups (2.71 +/- 0.54, 5.40 +/- 1.34, 6.13 +/- 0.71, 8.98 +/- 0.71 micrograms/mL) were attained between two to three hours following drug administration. The harmonic mean elimination half-life (4.5-6.5 hours), the mean total body clearance (4.45-4.85 mL/min/kg), the mean renal clearance (1.83-3.00 mL/min/kg), and the mean apparent volume of distribution (1.82-2.94 L/kg) were independent of dose, whereas the peak plasma concentrations and area under the curves increased as a linear function of dose. No significant side effects were observed at any dose level.


PMID: 4008675

DOI: 10.1002/j.1552-4604.1985.tb02841.x

Other references

Lange, H.; Berek, C.; Lemke, H., 1995: Maternal immunization to 2-phenyl-oxazolone causes an accelerated expression of high affinity antibodies during the primary anti-hapten response in the offspring. 9TH INTERNATIONAL CONGRESS OF IMMUNOLOGY [Author] The 9th International Congress of Immunology : 181

Mavi E.; Helge H.; Werner E., 1966: Metopirone diagnos test in children and young adults abstract from mschr kinderheilk 114 4 267 271 apr 1966 hypothalamic or pituitary disorders adrenal disease acth hormone synacthen hormone neopl tumor. Drug Digests 2(6): 354-355

Wessely, P., 1976: Therapy of the post-commotion syndrome. Wiener Medizinische Wochenschrift 126(10): 138-142

Shirakura, S.; Sano, J.; Karasawa, A.; Kubo, K., 1992: Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery. Evans blue (EB) was intravenously injected and its extravasation into the brain was determined as an indicator of disturbances in...

Burns, R.H.; Megaw, W.J., 1960: The law on radioactive wastes in Great Britain. The topics covered deal with: Legislation applicable to the United Kingdom Atomic Energy Authority, to licensed operators of nuclear reactors and to other users of radioactive materials.

Cottom, J.M.; Baker, J.S., 2016: Endoscopic Plantar Fascia Debridement for Chronic Plantar Fasciitis. When conservative therapy fails for chronic plantar fasciitis, surgical intervention may be an option. Surgical techniques that maintain the integrity of the plantar fascia will have less risk of destabilizing the foot and will retain foot functio...

Keverne, E.B.; Curley, J.P., 2004: Vasopressin, oxytocin and social behaviour. Understanding the neurobiology of social behaviour in mammals has been considerably advanced by the findings from two species of vole, one of which is monogamous and pair bonds whereas the other species is promiscuous and fails to form any long-la...

Neves, H., 1962: Trichophytin reaction in natural and experimental dermatophytosis and in tuberculosis. A comparative study, at Fac. Med. Univ. Lisbon, Portugal, of the trichophytin reaction in 170 cases of ringworm and 571 apparently uninfected subjects showed that immediate urticarial reactions were very rare, and non-infiltrative erythema was not...

Orr, L.P., 1968: The relative abundance of mimics and models in a supposed mimetic complex in salamanders. Journal of the Elisha Mitchell Scientific Society, 84: 303-304

Scozzarella, E., 1982: Smoke and health: medico-social aspects. Minerva Medica 73(36): 2409-2411