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Pharmacokinetics of paracetamol in ischemic cerebral apoplexy

, : Pharmacokinetics of paracetamol in ischemic cerebral apoplexy. Polish Journal of Pharmacology and Pharmacy 39(3): 259-265

Pharmacokinetics of paracetamol, regarded as a model substance, was investigated after oral administration to patients suffering from ischemic cerebral apoplexy. Twenty men, 50-70 years old, suffering from a brain stroke in the region of internal carotid artery or median cerebral artery on the left or right side, were tested 2 and 6 weeks after the onset of the stroke, and compared with a control group of 10 men. Essential differences in the pharmacokinetics of paracetamol were found between control subjects and those suffering from apoplexy. Disturbances in the cerebral circulation caused, regardless of the affected hemisphere, a depressed absorption of paracetamol, its larger distribution volume and increased elimination. Some pharmacokinetic parameters (tmax, Cmax, V2) were changed to a greater extent after 6 than after 2 weeks following the stroke. Some minor differences in the observed parameters, especially elimination, were noted in patients with a damage to the right and to the left hemispheres.


PMID: 3438211

Other references

Toaff, R.; Ayalon, D.; Gogol, G., 1971: Clinical use of high concentration oxytocin drip. Obstetrics and Gynecology 37(1): 112-120

Fraser, K.J.; Pulsen, K.; Haber, E., 1972: Specific cleavage between variable and constant domains of rabbit antibody light chains by dilute acid hydrolysis. Biochemistry 11(26): 4974-4977

Witzemann V.; Barg B.; Criado M.; Stein E.; Sakmann B., 1989: Developmental regulation of five subunit specific messenger rnas encoding acetylcholine receptor subtypes in rat muscle. Febs Letters 242(2): 419-424

Peck, G., A.; Smith, J.D.vid, 2000: Distribution of dissolved and particulate 226Ra, 210Pb and 210Po in the Bismarck Sea and western equatorial Pacific Ocean. The distribution of the radionuclides 226Ra, 210Pb and 210Po in the dissolved (<0.45 mum) and 210Pb and 210Po in the particulate (>0.45 mum) phases was measured in the upper 300 m of the Bismarck Sea off the Sepik River and along the equator...

Weisblat, D.A.; Stent, G.S., 1982: Cell lineage analysis by intracellular injection of tracer substances. Current Topics in Developmental Biology 17(Pt 3): 1-31

Zhan, B.; Shi, M-gong.; Li, Y-hao., 2006: Two cases of mercury poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23(6): 481-481

Vinson, S.B., 1968: The distribution of an oil, carbohydrate, and protein food source to members of the imported fire ant colony. The following is virtually the author's abstract. The distribution of sucrose, soy-bean oil and egg-yolk protein within colonies of Solenopsis saevissima richteri Forel was studied in the laboratory in Mississippi by means of dyed foods. The...

Milewicz, A.; Tworowska-Bardziñska, U.; Dunajska, K.; Jêdrzejuk, D.; Lwow, F., 2010: Relationship of PPARgamma2 polymorphism with obesity and metabolic syndrome in postmenopausal Polish women. The contribution of genetic factors to the development of menopausal obesity has been widely recognized. Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved in adipocyte differentiation and has been suggested to influence insu...

Taborda R.F.; Oropeza F.; Pulgar C.; Marquez P.J., 1967: Farming of grain sorghum m sorghum vulgare m in zulia state venezuela. Anon Reunion Latinoamericana De Fitotecnia Resumenes De Los Trabajos Cientificos Vii (7th Latin America Plant Technique Meeting ) Maracay, Venezuela, September 17-23, 291

Staquet, M.; Yabo, R.; Viktora, J.; Wolff, F., 1965: An Adrenergic Mechanism For Hyperglycemia Induced By Diazoxide. An intravenous injection of diazoxide in dogs leads to profound hypotension followed by an increase of the catecholamine blood level and hyperglycemia. A similar correlation was shown between the hypotensive action of nitroprusside and the resulti...